#LCSM Transcript
Healthcare social media transcript of the #LCSM hashtag.
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See #LCSM Influencers/Analytics.
| Profile | Tweet |
|---|---|
 | Brendon Stiles @BrendonStilesMD #lcsm |
 | Janet Freeman-Daily @JFreemanDaily Welcome to #LCSM Chat! Our topic for 11/29: “What’s a cancer model, and why should I care?” More info at https://t.co/AOxh5csDQw #LCSM |
 | Adam Marcus PhD @AdamMarcusPhD Ready for the #lcsm chat! |
 | #LCSM Chat @lcsmchat RT @JFreemanDaily: Welcome to #LCSM Chat! Our topic for 11/29: Welcome to #LCSM Chat! Our topic for 11/29: “What’s a cancer model, and why should I care?” More info at https://t.co/AOxh5csDQw #LCSM |
| Brendon Stiles @BrendonStilesMD Hope everyone is well. Looking forward to hearing thoughts this evening about different lung cancer models. #lcsm |
 | Faces of Lung Cancer @LungCancerFaces RT @JFreemanDaily: Welcome to #LCSM Chat! Our topic for 11/29: Welcome to #LCSM Chat! Our topic for 11/29: “What’s a cancer model, and why should I care?” More info at https://t.co/AOxh5csDQw #LCSM |
| Janet Freeman-Daily @JFreemanDaily Hey Adam and Brendon! #lcsm |
 | Lung Cancer Sux @LungCancerSux @BrendonStilesMD Bonsoir! #lcsm |
| Janet Freeman-Daily @JFreemanDaily Welcome Bob and Andrea! #lcsm |
 | Bob Steele @steele_bob RT @JFreemanDaily: Welcome to #LCSM Chat! Our topic for 11/29: Welcome to #LCSM Chat! Our topic for 11/29: “What’s a cancer model, and why should I care?” More info at https://t.co/AOxh5csDQw #LCSM |
 | NCI Cancer Stats @NCICancerStats Lung cancer is the leading cause of death for both men and women in the United States. Watch our DYK video for more info: https://t.co/MnrkjeW1f2 #LCAM #LCSM |
 | Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD Tim here. #lcsm |
| Janet Freeman-Daily @JFreemanDaily I’m your moderator Janet Freeman-Daily: writer (https://t.co/OBCc88h7Jg), science geek, stage IV #lungcancer patient/activist #lcsm |
| Janet Freeman-Daily @JFreemanDaily Hiya Time! #lcsm |
 | Karen Loss @cancertrek Hi folks. Karen here...at least for a bit. #lcsm |
 | Christine Qiong Wu @CQiongWu @JFreemanDaily @lcsmchat I'm here. #LCSM |
| Adam Marcus PhD @AdamMarcusPhD RT @NCICancerStats: Lung cancer is the leading cause of death for both men and women in the United States. Watch our DYK video for more info: https://t.co/MnrkjeW1f2 #LCAM #LCSM |
| Janet Freeman-Daily @JFreemanDaily OK, it's Tim, not Time, but hey -- you can never have enough time. #lcsm |
| #LCSM Chat @lcsmchat Deana @LungCancerFaces here manning the #LCSM Chat account. |
| Janet Freeman-Daily @JFreemanDaily Welcome Karen and Christine! #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: I’m your moderator Janet Freeman-Daily: I’m your moderator Janet Freeman-Daily: writer (https://t.co/OBCc88h7Jg), science geek, stage IV #lungcancer patient/activist #lcsm |
| Janet Freeman-Daily @JFreemanDaily We'll get started in a few minutes -- please take a moment to introduce yourselves #lcsm |
 | Deb Smith 🌻🟧 @debsmithbeach @LynnPatterson @cancertrek I passed 7 yrs post dx with stage 4 LC in August, last 5 yrs on Tagrisso. There are more options and more survivors every year! Take care. #LCSM |
| Brendon Stiles @BrendonStilesMD I resected three lung cancers the last 2 days. Two were second primary tumors for each patient. Would make incredible models to study similarities and differences. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD Autocorrect FTW #LCSM |
| Janet Freeman-Daily @JFreemanDaily Just curious -- how many of your have experience with cancer models? #lcsm |
| Bob Steele @steele_bob I'm really looking forward to learning about cancer models from tonight's Lung Cancer Social Media Twitter Chat group! #lcsm |
| #LCSM Chat @lcsmchat RT @debsmithbeach: @LynnPatterson @cancertrek I passed 7 yrs post dx with stage 4 LC in August, last 5 yrs on Tagrisso. There are more options and more survivors every year! Take care. #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: I resected three lung cancers the last 2 days. Two were second primary tumors for each patient. Would make incredible models to study similarities and differences. #lcsm |
| Brendon Stiles @BrendonStilesMD The other was in a never smoker. Also ripe for PDX/cell based laboratory models given reasonably high chance of targetable mutation. #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Just curious -- how many of your have experience with cancer models? #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Just curious -- how many of your have experience with cancer models? #lcsm |
 | Devika Das, MD, MSHQS @DevikaDasMD @BrendonStilesMD Following #lcsm |
| Lung Cancer Sux @LungCancerSux @JFreemanDaily None #lcsm |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: The other was in a never smoker. Also ripe for PDX/cell based laboratory models given reasonably high chance of targetable mutation. #lcsm |
| Janet Freeman-Daily @JFreemanDaily If you are new to Twitter chats and/or #LCSM Chat, you might find our primer on how to participate helpful https://t.co/5g28sSQQLb #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: If you are new to Twitter chats and/or #LCSM Chat, you might find our primer on how to participate helpful https://t.co/5g28sSQQLb #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: If you are new to Twitter chats and/or #LCSM Chat, you might find our primer on how to participate helpful https://t.co/5g28sSQQLb #LCSM |
| Faces of Lung Cancer @LungCancerFaces RT @JFreemanDaily: If you are new to Twitter chats and/or #LCSM Chat, you might find our primer on how to participate helpful https://t.co/5g28sSQQLb #LCSM |
| Brendon Stiles @BrendonStilesMD I have experience with organoid and pdx models. #lcsm |
| Deb Smith 🌻🟧 @debsmithbeach Deb here, housesitting in snowy western Maine. Stable scans Tuesday! Can't keep eyes open after long drive north today. #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: I have experience with organoid and pdx models. #lcsm |
 | Peggy Dennis @peggyddennis Peggy joining from Denver #lcsm |
| Brendon Stiles @BrendonStilesMD @debsmithbeach Congratulations on the stable scan! #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD Congratulations! #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: I have experience with organoid and pdx models. #lcsm |
 | Enlightening Results 💡 @GraceCordovano Hi #lcsm friends! Peeking in to say hello while I rally the troops to bed. Will be listening & learning. https://t.co/wbqxXRcbZs |
| Janet Freeman-Daily @JFreemanDaily Please remember to use #lcsm in all your tweets so others participating in the chat can see them |
| Christine Qiong Wu @CQiongWu @JFreemanDaily @lcsmchat Very little knowledge about cancer model #LCSM |
| Janet Freeman-Daily @JFreemanDaily @debsmithbeach Congrats on the stable scans! Woohoo! #LCSM |
| Bob Steele @steele_bob @debsmithbeach Awesome to hear you had stable scans! #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Please remember to use #lcsm in all your tweets so others participating in the chat can see them |
 | Denise Cutlip @dennycee Hey all. Looking to learn more about this tonight #lcsm |
| Janet Freeman-Daily @JFreemanDaily If you prefer just to listen, please tweet “#LCSM” so we know you’re in the audience #LCSM |
| #LCSM Chat @lcsmchat ICYMI, @cancertrek just celebrated her 6 year cancerversary! #LCSM |
| Bob Steele @steele_bob I have no experience with cancer models. Been doing a little reading about it. #lcsm |
| Janet Freeman-Daily @JFreemanDaily Note: Twitter allows tweets up to 280 characters, but some tweetchat apps (like https://t.co/A2M7gXQ66L) will not display tweets longer than 140. If you use an app, you might miss some content. #LCSM |
 | Katie Brown @brownbeansprout @VirginiaMByrne Definitely not a "job" for me or my staff at @LUNGevity weve all lost loved ones & friends. My dad, best friend, other family members. I'm also surviving an incurable disease too so I know the importance of advocacy. It IS life & death. Pls know we are working very hard #lcsm |
 | Inspire @InspireIsHealth Hello to #LCSM, John Novack here from Inspire. |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: If you prefer just to listen, please tweet “#LCSM” so we know you’re in the audience #LCSM |
| Inspire @InspireIsHealth RT @JFreemanDaily: Welcome to #LCSM Chat! Our topic for 11/29: Welcome to #LCSM Chat! Our topic for 11/29: “What’s a cancer model, and why should I care?” More info at https://t.co/AOxh5csDQw #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Note: Note: Twitter allows tweets up to 280 characters, but some tweetchat apps (like https://t.co/A2M7gXQ66L) will not display tweets longer than 140. If you use an app, you might miss some content. #LCSM |
| Janet Freeman-Daily @JFreemanDaily I will announce FIVE topics (T1 T2 etc). Pls label your answers with T1, T2, etc to make transcript easier to follow. #LCSM |
| Deb Smith 🌻🟧 @debsmithbeach @JFreemanDaily None for me. #LCSM |
| Janet Freeman-Daily @JFreemanDaily We’ll start with Topic T1 in a minute … #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: I will announce FIVE topics (T1 T2 etc). Pls label your answers with T1, T2, etc to make transcript easier to follow. #LCSM |
| Janet Freeman-Daily @JFreemanDaily T1: What are cancer models? What types of cancer models are currently used? #LCSM |
| Karen Loss @cancertrek True dat! RT @lcsmchat: ICYMI, @cancertrek just celebrated her 6 year cancerversary! #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: T1: T1: What are cancer models? What types of cancer models are currently used? #LCSM |
| Faces of Lung Cancer @LungCancerFaces RT @JFreemanDaily: I will announce FIVE topics (T1 T2 etc). Pls label your answers with T1, T2, etc to make transcript easier to follow. #LCSM |
| Brendon Stiles @BrendonStilesMD All kinds of models exist. Classic is commercially available human cell lines, which can be tested in culture or in mice without immune systems. Like the famous HeLa cells. #lcsm |
| Adam Marcus PhD @AdamMarcusPhD T1: Cancer models allow us to study how tumors behave outside the body. Numerous models- cell lines, patient derived organoids, patient derived xenograft. Also non-human models like mice and flies like Drosophila #LCSM |
| Faces of Lung Cancer @LungCancerFaces RT @JFreemanDaily: T1: T1: What are cancer models? What types of cancer models are currently used? #LCSM |
| Janet Freeman-Daily @JFreemanDaily Cancer models are clumps of living cancer cells that exist either in a lab dish or in animal models such as mice. We can't study cells in humans, so this is another way to study cancer's behavior and response to drugs. #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: All kinds of models exist. Classic is commercially available human cell lines, which can be tested in culture or in mice without immune systems. Like the famous HeLa cells. #lcsm |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T1: T1: Cancer models allow us to study how tumors behave outside the body. Numerous models- cell lines, patient derived organoids, patient derived xenograft. Also non-human models like mice and flies like Drosophila #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Cancer models are clumps of living cancer cells that exist either in a lab dish or in animal models such as mice. We can't study cells in humans, so this is another way to study cancer's behavior and response to drugs. #LCSM |
 | Ranjeet Kumar @strategicpolicy RT @NCICancerStats: Lung cancer is the leading cause of death for both men and women in the United States. Watch our DYK video for more info: https://t.co/MnrkjeW1f2 #LCAM #LCSM |
| Janet Freeman-Daily @JFreemanDaily Sometimes these models also include other living cells from the host environment. It’s not exactly the same as studying a living cancer in its human host, but it does allow researchers time to study the biology of a cancer and test different treatments against it. #LCSM |
| Adam Marcus PhD @AdamMarcusPhD T1: Cancer models allow us to "manipulate" the tumor cells in ways that we could not do in a human to better understand how it works. IMO the only way to cure is to understand how it works! #LCSM |
 | KC Dill @kasedill Hello from TX. Ready to learn #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Sometimes these models also include other living cells from the host environment. It’s not exactly the same as studying a living cancer in its human host, but it does allow researchers time to study the biology of a cancer and test different treatments against it. #LCSM |
| Deb Smith 🌻🟧 @debsmithbeach RT @lcsmchat: ICYMI, @cancertrek just celebrated her 6 year cancerversary! #LCSM |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T1: T1: Cancer models allow us to "manipulate" the tumor cells in ways that we could not do in a human to better understand how it works. IMO the only way to cure is to understand how it works! #LCSM |
| Brendon Stiles @BrendonStilesMD T1. You can also induce mutations in cells the lungs of mice (KRAS, p53, EGFR) so that they develop spontaneous tumors. Cell lines can also be developed from these. We use them frequently to study specific types of lung cancer in mice with intact immune systems. #lcsm |
| Karen Loss @cancertrek T1: @JFreemanDaily Mouse models? Computer models? #lcsm |
 | Jennifer Ersek @JLErsek Whats up #LCSM community? Its been awhile. Excited about tonights convo |
| Janet Freeman-Daily @JFreemanDaily One type of cancer model is cell lines. Have you ever heard of "The Immortal Life of Henrietta Lacks" and the HeLa cell line? Cell lines are clumps of cells that are immortal and can be used for experiments. #LCSM https://t.co/gGAJc4HeYz |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: T1. You can also induce mutations in cells the lungs of mice (KRAS, p53, EGFR) so that they develop spontaneous tumors. Cell lines can also be developed from these. We use them frequently to study specific types of lung cancer in mice with intact immune systems. #lcsm |
| Brendon Stiles @BrendonStilesMD T1. Can also make models directly from fresh patient derived tumor material. These are called patient derived xenografts (PDX). These can be hard to get to "take". The mice have to be very immune suppressed. #lcsm |
 | Anita Figueras @scifiknitter Hello from snowy NNY! Anita from the EGFR Resisters here. Great topic, we've just launched a study to make PDX models of resistant EGFR cancers. #LCSM |
| #LCSM Chat @lcsmchat RT @cancertrek: T1: T1: @JFreemanDaily Mouse models? Computer models? #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: One type of cancer model is cell lines. Have you ever heard of "The Immortal Life of Henrietta Lacks" and the HeLa cell line? Cell lines are clumps of cells that are immortal and can be used for experiments. #LCSM https://t.co/gGAJc4HeYz |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: T1. Can also make models directly from fresh patient derived tumor material. These are called patient derived xenografts (PDX). These can be hard to get to "take". The mice have to be very immune suppressed. #lcsm |
| Adam Marcus PhD @AdamMarcusPhD T1: Example of a lung cancer cell line we have https://t.co/DKU2HmiOi1 #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: T1. Can also make models directly from fresh patient derived tumor material. These are called patient derived xenografts (PDX). These can be hard to get to "take". The mice have to be very immune suppressed. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: One type of cancer model is cell lines. Have you ever heard of "The Immortal Life of Henrietta Lacks" and the HeLa cell line? Cell lines are clumps of cells that are immortal and can be used for experiments. #LCSM https://t.co/gGAJc4HeYz |
| Brendon Stiles @BrendonStilesMD T1. Final model we sometimes use are "organoid" models, in which we try to grow several types of patients cells together in a dish. #lcsm |
| #LCSM Chat @lcsmchat RT @scifiknitter: Hello from snowy NNY! Anita from the EGFR Resisters here. Great topic, we've just launched a study to make PDX models of resistant EGFR cancers. #LCSM |
| Bob Steele @steele_bob RT @Notmadscientist: T1: T1: Example of a lung cancer cell line we have https://t.co/DKU2HmiOi1 #LCSM |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T1: T1: Example of a lung cancer cell line we have https://t.co/DKU2HmiOi1 #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: T1. You can also induce mutations in cells the lungs of mice (KRAS, p53, EGFR) so that they develop spontaneous tumors. Cell lines can also be developed from these. We use them frequently to study specific types of lung cancer in mice with intact immune systems. #lcsm |
| Jennifer Ersek @JLErsek @JFreemanDaily @lcsmchat I don’t #lcsm |
| KC Dill @kasedill RT @JFreemanDaily: One type of cancer model is cell lines. Have you ever heard of "The Immortal Life of Henrietta Lacks" and the HeLa cell line? Cell lines are clumps of cells that are immortal and can be used for experiments. #LCSM https://t.co/gGAJc4HeYz |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T1: T1: Cancer models allow us to "manipulate" the tumor cells in ways that we could not do in a human to better understand how it works. IMO the only way to cure is to understand how it works! #LCSM |
| Anita Figueras @scifiknitter RT @Notmadscientist: T1: T1: Cancer models allow us to "manipulate" the tumor cells in ways that we could not do in a human to better understand how it works. IMO the only way to cure is to understand how it works! #LCSM |
| Bob Steele @steele_bob RT @BrendonStilesMD: T1. Final model we sometimes use are "organoid" models, in which we try to grow several types of patients cells together in a dish. #lcsm |
| Janet Freeman-Daily @JFreemanDaily @cancertrek Yes, several types of mouse models exist. Patient-derived xenograft models are clumps of human cancers cells and environment that's injected into a mouse to allow the cells to grow and divide. #LCSM |
 | Geri Massa @GeriGerim13 Hi y’all , I just realized what time it is .... #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Sometimes these models also include other living cells from the host environment. It’s not exactly the same as studying a living cancer in its human host, but it does allow researchers time to study the biology of a cancer and test different treatments against it. #LCSM |
 | MD Anderson Cancer Center @MDAndersonNews How #bigdata is helping make breakthroughs in #lungcancer treatments: https://t.co/kRqFqAVjuh @CancerFrontline #CancerMoonshot #LCSM #endcancer |
| Brendon Stiles @BrendonStilesMD Here is a good review from 2015.https://t.co/pQlHfv6OlM Science is still evolving. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: All kinds of models exist. Classic is commercially available human cell lines, which can be tested in culture or in mice without immune systems. Like the famous HeLa cells. #lcsm |
| Anita Figueras @scifiknitter RT @JFreemanDaily: One type of cancer model is cell lines. Have you ever heard of "The Immortal Life of Henrietta Lacks" and the HeLa cell line? Cell lines are clumps of cells that are immortal and can be used for experiments. #LCSM https://t.co/gGAJc4HeYz |
| Bob Steele @steele_bob RT @BrendonStilesMD: Here is a good review from 2015.https://t.co/pQlHfv6OlM Science is still evolving. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: @cancertrek Yes, several types of mouse models exist. Patient-derived xenograft models are clumps of human cancers cells and environment that's injected into a mouse to allow the cells to grow and divide. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: T1. Final model we sometimes use are "organoid" models, in which we try to grow several types of patients cells together in a dish. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T1: T1: Example of a lung cancer cell line we have https://t.co/DKU2HmiOi1 #LCSM |
| Anita Figueras @scifiknitter RT @BrendonStilesMD: T1. Can also make models directly from fresh patient derived tumor material. These are called patient derived xenografts (PDX). These can be hard to get to "take". The mice have to be very immune suppressed. #lcsm |
| Anita Figueras @scifiknitter RT @BrendonStilesMD: T1. Final model we sometimes use are "organoid" models, in which we try to grow several types of patients cells together in a dish. #lcsm |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: T1. Final model we sometimes use are "organoid" models, in which we try to grow several types of patients cells together in a dish. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: Here is a good review from 2015.https://t.co/pQlHfv6OlM Science is still evolving. #lcsm |
| Adam Marcus PhD @AdamMarcusPhD T1: We have about 10 lung cancer patient derived organoids from consented patients @WinshipAtEmory These are extremely valuable to dissect driver mutations and biology #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: @cancertrek Yes, several types of mouse models exist. Patient-derived xenograft models are clumps of human cancers cells and environment that's injected into a mouse to allow the cells to grow and divide. #LCSM |
| Janet Freeman-Daily @JFreemanDaily There are also "genetically engineered mice" (GEM) whose DNA is changed to induce cancer. These are useful when you want to study the immune response to a drug. #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: Here is a good review from 2015.https://t.co/pQlHfv6OlM Science is still evolving. #lcsm |
| Inspire @InspireIsHealth RT @BrendonStilesMD: Here is a good review from 2015.https://t.co/pQlHfv6OlM Science is still evolving. #lcsm |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T1: T1: We have about 10 lung cancer patient derived organoids from consented patients @WinshipAtEmory These are extremely valuable to dissect driver mutations and biology #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: There are also "genetically engineered mice" (GEM) whose DNA is changed to induce cancer. These are useful when you want to study the immune response to a drug. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T1: T1: We have about 10 lung cancer patient derived organoids from consented patients @WinshipAtEmory These are extremely valuable to dissect driver mutations and biology #lcsm |
| Deb Smith 🌻🟧 @debsmithbeach T1 Thanks for explaining the term cancer models! At least I've read the Skloot book on HeLa. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: There are also "genetically engineered mice" (GEM) whose DNA is changed to induce cancer. These are useful when you want to study the immune response to a drug. #LCSM |
| Janet Freeman-Daily @JFreemanDaily Most PDX mice have had their immune system suppressed so they won't reject the human cancers cells. They are not useful for studying immunotherapies. #LCSM |
| Janet Freeman-Daily @JFreemanDaily Topic T2 is coming up … #LCSM |
| Anita Figueras @scifiknitter RT @JFreemanDaily: There are also "genetically engineered mice" (GEM) whose DNA is changed to induce cancer. These are useful when you want to study the immune response to a drug. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Most PDX mice have had their immune system suppressed so they won't reject the human cancers cells. They are not useful for studying immunotherapies. #LCSM |
| Geri Massa @GeriGerim13 I know I ask this everytime, how do I see the chat as it’s happening. Tao .... something like that #LCSM |
 | Nichole @MappingMomLife RT @MomNeedsABottle: #ad November is Lung Cancer Awareness Month. In the US alone we account for approximately 154,000 deaths. You are your own best advocate! More info at LIVE W.E.L.L. https://t.co/ogwYtruylm @AstraZenecaUS #LCSM #LCAM https://t.co/DpvyZwAiff |
| Janet Freeman-Daily @JFreemanDaily I am not aware of any computer models of cancer. @BrendonStilesMD do you know of any? #LCSM |
 | Tatanisha @tatanishapw RT @MomNeedsABottle: #ad November is Lung Cancer Awareness Month. In the US alone we account for approximately 154,000 deaths. You are your own best advocate! More info at LIVE W.E.L.L. https://t.co/ogwYtruylm @AstraZenecaUS #LCSM #LCAM https://t.co/DpvyZwAiff |
| Adam Marcus PhD @AdamMarcusPhD T1: Example of lung cancer imaging in a genetic mouse model #LCSM https://t.co/QFfwmIJJCW |
| Janet Freeman-Daily @JFreemanDaily T2: How are cell lines created, and how are they used in research? #LCSM |
| #LCSM Chat @lcsmchat @GeriGerim13 You're better off simply searching #lcsm in twitter and refreshing over and over. |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: I am not aware of any computer models of cancer. @BrendonStilesMD do you know of any? #LCSM |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T1: T1: Example of lung cancer imaging in a genetic mouse model #LCSM https://t.co/QFfwmIJJCW |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: T2: T2: How are cell lines created, and how are they used in research? #LCSM |
 | Eliana Marin Rivera @Eliana_marin2 RT @MDAndersonNews: How #bigdata is helping make breakthroughs in #lungcancer treatments: How #bigdata is helping make breakthroughs in #lungcancer treatments: https://t.co/kRqFqAVjuh @CancerFrontline #CancerMoonshot #LCSM #endcancer |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: T2: T2: How are cell lines created, and how are they used in research? #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T1: T1: Example of lung cancer imaging in a genetic mouse model #LCSM https://t.co/QFfwmIJJCW |
| Janet Freeman-Daily @JFreemanDaily Making a cell line requires collecting FRESH tumor tissue from a patient (like a biopsy or surgery) and processing it to make the cells stay alive outside the body indefinitely. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Most PDX mice have had their immune system suppressed so they won't reject the human cancers cells. They are not useful for studying immunotherapies. #LCSM |
| Adam Marcus PhD @AdamMarcusPhD T2: Cell lines are created now from the tumors of consented patients, but can also be made from mouse tumors. #LCSM |
| Anita Figueras @scifiknitter @lcsmchat @GeriGerim13 That's what works for me! #LCSM |
| Faces of Lung Cancer @LungCancerFaces RT @JFreemanDaily: T2: T2: How are cell lines created, and how are they used in research? #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Making a cell line requires collecting FRESH tumor tissue from a patient (like a biopsy or surgery) and processing it to make the cells stay alive outside the body indefinitely. #LCSM |
| Karen Loss @cancertrek RT @Notmadscientist: T2: T2: Cell lines are created now from the tumors of consented patients, but can also be made from mouse tumors. #LCSM |
| Brendon Stiles @BrendonStilesMD @JFreemanDaily I feel like I have seen a couple grants that were over my head, but I don't have a good grasp of them. That said, much of data we get from these current models is heavily driven by computational algorithms evaluating different cell populations and evolution. #lcsm |
| Janet Freeman-Daily @JFreemanDaily Cell lines can also be made from cancer cells collect from pleural fluid. However, to my knowledge, cell lines for lung cancer cannot be made from cells collected from blood samples. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Making a cell line requires collecting FRESH tumor tissue from a patient (like a biopsy or surgery) and processing it to make the cells stay alive outside the body indefinitely. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T2: T2: Cell lines are created now from the tumors of consented patients, but can also be made from mouse tumors. #LCSM |
| Jennifer Ersek @JLErsek @lcsmchat @GeriGerim13 Thats how I do it! Heres a screenshot of where to go #lcsm https://t.co/etEr50WGnZ |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T2: T2: Cell lines are created now from the tumors of consented patients, but can also be made from mouse tumors. #LCSM |
| Adam Marcus PhD @AdamMarcusPhD T2: Cell lines are used in many types of studies- genetic analysis, molecular studies, drug discovery, computer modeling studies #LCSM |
 | Jennasmith @Jennasm66663888 RT @pamelamaynard: Did you know lung cancer is the leading cause of cancer death among both men & women, accounting for approximately 154,000 deaths each year - that's 1/4 of all cancer deaths - Find out more during Lung Cancer Awareness Month https://t.co/zzZNxUSugO #LCSM #LCAM #ad @AstraZenecaUS https://t.co/IVBTdSYadG |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: @JFreemanDaily I feel like I have seen a couple grants that were over my head, but I don't have a good grasp of them. That said, much of data we get from these current models is heavily driven by computational algorithms evaluating different cell populations and evolution. #lcsm |
| Anita Figueras @scifiknitter RT @JFreemanDaily: Making a cell line requires collecting FRESH tumor tissue from a patient (like a biopsy or surgery) and processing it to make the cells stay alive outside the body indefinitely. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Cell lines can also be made from cancer cells collect from pleural fluid. However, to my knowledge, cell lines for lung cancer cannot be made from cells collected from blood samples. #LCSM |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T2: T2: Cell lines are used in many types of studies- genetic analysis, molecular studies, drug discovery, computer modeling studies #LCSM |
| Anita Figueras @scifiknitter RT @JFreemanDaily: Cell lines can also be made from cancer cells collect from pleural fluid. However, to my knowledge, cell lines for lung cancer cannot be made from cells collected from blood samples. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Cell lines can also be made from cancer cells collect from pleural fluid. However, to my knowledge, cell lines for lung cancer cannot be made from cells collected from blood samples. #LCSM |
| Brendon Stiles @BrendonStilesMD T2. Knocking on the door of immortality. https://t.co/RDArIvizcf #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: @JFreemanDaily I feel like I have seen a couple grants that were over my head, but I don't have a good grasp of them. That said, much of data we get from these current models is heavily driven by computational algorithms evaluating different cell populations and evolution. #lcsm |
| Janet Freeman-Daily @JFreemanDaily Cell lines look like liquid. They can be frozen and shipped to other researchers for study. #LCSM https://t.co/eLpnUSEfBs |
| Bob Steele @steele_bob RT @Notmadscientist: T2: T2: Cell lines are created now from the tumors of consented patients, but can also be made from mouse tumors. #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: T2. Knocking on the door of immortality. https://t.co/RDArIvizcf #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T2: T2: Cell lines are used in many types of studies- genetic analysis, molecular studies, drug discovery, computer modeling studies #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Cell lines look like liquid. They can be frozen and shipped to other researchers for study. #LCSM https://t.co/eLpnUSEfBs |
| Bob Steele @steele_bob RT @BrendonStilesMD: T2. Knocking on the door of immortality. https://t.co/RDArIvizcf #lcsm |
| Anita Figueras @scifiknitter RT @JFreemanDaily: Cell lines look like liquid. They can be frozen and shipped to other researchers for study. #LCSM https://t.co/eLpnUSEfBs |
 | Chidambara .ML. @chidambara09 RT @MDAndersonNews: How #bigdata is helping make breakthroughs in #lungcancer treatments: How #bigdata is helping make breakthroughs in #lungcancer treatments: https://t.co/kRqFqAVjuh @CancerFrontline #CancerMoonshot #LCSM #endcancer |
| Janet Freeman-Daily @JFreemanDaily Cell lines can also be used to tests different drugs in different concentrations against a particular cell line. Good for finding drugs to overcome resistance mutations. #LCSM https://t.co/1nvFiHjHdX |
| Janet Freeman-Daily @JFreemanDaily @BrendonStilesMD I can see you've prepared well for this chat! Thanks for the resources and pictures! #LCSM |
| Janet Freeman-Daily @JFreemanDaily We’ll shift to Topic T3 next … #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Cell lines can also be used to tests different drugs in different concentrations against a particular cell line. Good for finding drugs to overcome resistance mutations. #LCSM https://t.co/1nvFiHjHdX |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Cell lines look like liquid. They can be frozen and shipped to other researchers for study. #LCSM https://t.co/eLpnUSEfBs |
| Brendon Stiles @BrendonStilesMD T2. A great read for those of you who haven't come across it. Fortunately times have changed and consent is required, along with some description of potential uses. #lcsm https://t.co/mkiPimK5qW |
| Anita Figueras @scifiknitter RT @JFreemanDaily: Cell lines can also be used to tests different drugs in different concentrations against a particular cell line. Good for finding drugs to overcome resistance mutations. #LCSM https://t.co/1nvFiHjHdX |
| Brendon Stiles @BrendonStilesMD @JFreemanDaily Believe it or not, I am actually finding this on the fly. But it is a critical topic for people to understand and support. This is the engine that drives cancer research. And #ResearchBeatsCancer. #lcsm |
| Anita Figueras @scifiknitter RT @BrendonStilesMD: T2. A great read for those of you who haven't come across it. Fortunately times have changed and consent is required, along with some description of potential uses. #lcsm https://t.co/mkiPimK5qW |
| Janet Freeman-Daily @JFreemanDaily T3: How are Patient-Derived Xenograft (PDX) mice models made, and how are they used in research? #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Cell lines can also be used to tests different drugs in different concentrations against a particular cell line. Good for finding drugs to overcome resistance mutations. #LCSM https://t.co/1nvFiHjHdX |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: T2. A great read for those of you who haven't come across it. Fortunately times have changed and consent is required, along with some description of potential uses. #lcsm https://t.co/mkiPimK5qW |
| KC Dill @kasedill RT @BrendonStilesMD: T2. A great read for those of you who haven't come across it. Fortunately times have changed and consent is required, along with some description of potential uses. #lcsm https://t.co/mkiPimK5qW |
| Peggy Dennis @peggyddennis Who are researchers looking for in regards to developing cell lines and how would patients know? #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: T3: T3: How are Patient-Derived Xenograft (PDX) mice models made, and how are they used in research? #LCSM |
 | Matthew Katz, MD 🟦 @subatomicdoc Good evening! Sorry to join late. Matt Katz, radiation oncologist. I hope you're all well. #lcsm |
| Faces of Lung Cancer @LungCancerFaces RT @JFreemanDaily: T3: T3: How are Patient-Derived Xenograft (PDX) mice models made, and how are they used in research? #LCSM |
| Matthew Katz, MD 🟦 @subatomicdoc RT @JFreemanDaily: T3: T3: How are Patient-Derived Xenograft (PDX) mice models made, and how are they used in research? #LCSM |
| Janet Freeman-Daily @JFreemanDaily PDX mouse models begin fresh tissue or cells from pleural fluid just like cell lines . Because the tissue is implanted in a mouse and must grow for a while, PDX models take longer and cost more. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: T3: T3: How are Patient-Derived Xenograft (PDX) mice models made, and how are they used in research? #LCSM |
 | Olumuyiwa Adeboye 🇳🇬🇬🇩🇧🇶🇦🇼🇺🇸 @moyecome RT @LCAorg: Join us for a #ShineaLight18 awareness event at your local healthcare facility! Hear from doctors in the field on the latest treatments and research, as well as personal stories and experiences from survivors. Find a free event near you! #LCSM #LCAM >> https://t.co/AOfCr1F6Qk |
| Adam Marcus PhD @AdamMarcusPhD T3: Piece of a patient tumor is put onto a mouse to grow there. In this way the patient's tumor can be further studied #LCSM |
| #LCSM Chat @lcsmchat RT @peggyddennis: Who are researchers looking for in regards to developing cell lines and how would patients know? #LCSM |
| Brendon Stiles @BrendonStilesMD T3. For us, we take tumors directly from consented patients in the OR in a special solution and then implant small pieces into the sides of immune suppressed mice. We have a core facility that can do it for almost any tumor. #lcsm |
| Anita Figueras @scifiknitter RT @JFreemanDaily: PDX mouse models begin fresh tissue or cells from pleural fluid just like cell lines . Because the tissue is implanted in a mouse and must grow for a while, PDX models take longer and cost more. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: PDX mouse models begin fresh tissue or cells from pleural fluid just like cell lines . Because the tissue is implanted in a mouse and must grow for a while, PDX models take longer and cost more. #LCSM |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T3: T3: Piece of a patient tumor is put onto a mouse to grow there. In this way the patient's tumor can be further studied #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: T3. For us, we take tumors directly from consented patients in the OR in a special solution and then implant small pieces into the sides of immune suppressed mice. We have a core facility that can do it for almost any tumor. #lcsm |
| Janet Freeman-Daily @JFreemanDaily @peggyddennis Not sure what you mean. Patients at research hospitals that make cell lines may be asked to donate--I've already consented that if my cancer progresses, University of Colorado will take a biopsy and try to make a cell line. #LCSM |
| Inspire @InspireIsHealth RT @BrendonStilesMD: T2. Knocking on the door of immortality. https://t.co/RDArIvizcf #lcsm |
| Bob Steele @steele_bob RT @Notmadscientist: T3: T3: Piece of a patient tumor is put onto a mouse to grow there. In this way the patient's tumor can be further studied #LCSM |
| Janet Freeman-Daily @JFreemanDaily There are also research studies for which patients can volunteer that collect tissue to make cancer models. The ROS1 Cancer Model Project does this. Patients' tissue is shipped to the research center. #LCSM |
| Brendon Stiles @BrendonStilesMD t3. Once a PDX tumor "takes" and starts to grow, it can be split up into many more tumors and each could in theory be tested in a mini "clinical trial" in the lab using different drugs. #lcsm |
| Janet Freeman-Daily @JFreemanDaily EGFR Resisters also have a project to create cancer models. So does the Borad Institute--part of their "Rare Cancers Dependencies Map" project. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: @peggyddennis Not sure what you mean. Patients at research hospitals that make cell lines may be asked to donate--I've already consented that if my cancer progresses, University of Colorado will take a biopsy and try to make a cell line. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: There are also research studies for which patients can volunteer that collect tissue to make cancer models. The ROS1 Cancer Model Project does this. Patients' tissue is shipped to the research center. #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: t3. Once a PDX tumor "takes" and starts to grow, it can be split up into many more tumors and each could in theory be tested in a mini "clinical trial" in the lab using different drugs. #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: EGFR Resisters also have a project to create cancer models. So does the Borad Institute--part of their "Rare Cancers Dependencies Map" project. #LCSM |
| KC Dill @kasedill So basically Dr. Sikora is using eggs in relation to cancer models? #lcsm |
| Karen Loss @cancertrek @Notmadscientist Why are mouse grown tumors better than petri dish studies using the same tissue cells? #lcsm |
| Bob Steele @steele_bob I'm scrambling as fast as I can to scan the resources being posted. This is definitely going to take some time. LOL #lcsm |
| #LCSM Chat @lcsmchat RT @cancertrek: @Notmadscientist Why are mouse grown tumors better than petri dish studies using the same tissue cells? #lcsm |
| Adam Marcus PhD @AdamMarcusPhD The mouse represents a closer environment to where the original tumor was in the body as compared to a petri dish. The mouse is far from perfect though #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: PDX mouse models begin fresh tissue or cells from pleural fluid just like cell lines . Because the tissue is implanted in a mouse and must grow for a while, PDX models take longer and cost more. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T3: T3: Piece of a patient tumor is put onto a mouse to grow there. In this way the patient's tumor can be further studied #LCSM |
| Brendon Stiles @BrendonStilesMD @cancertrek @Notmadscientist They better reflect the environment of human tumors with lots of other cells and physiological factors interacting. Can also be used in setting of an intact immune system. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: T3. For us, we take tumors directly from consented patients in the OR in a special solution and then implant small pieces into the sides of immune suppressed mice. We have a core facility that can do it for almost any tumor. #lcsm |
| #LCSM Chat @lcsmchat RT @steele_bob: I'm scrambling as fast as I can to scan the resources being posted. This is definitely going to take some time. LOL #lcsm |
| Bob Steele @steele_bob RT @cancertrek: @Notmadscientist Why are mouse grown tumors better than petri dish studies using the same tissue cells? #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: @peggyddennis Not sure what you mean. Patients at research hospitals that make cell lines may be asked to donate--I've already consented that if my cancer progresses, University of Colorado will take a biopsy and try to make a cell line. #LCSM |
| Matthew Katz, MD 🟦 @subatomicdoc RT @JFreemanDaily: There are also research studies for which patients can volunteer that collect tissue to make cancer models. The ROS1 Cancer Model Project does this. Patients' tissue is shipped to the research center. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: There are also research studies for which patients can volunteer that collect tissue to make cancer models. The ROS1 Cancer Model Project does this. Patients' tissue is shipped to the research center. #LCSM |
| Janet Freeman-Daily @JFreemanDaily @cancertrek @Notmadscientist @cancertrek You're anticipating T4! I'm typing as fast as I can ... #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: t3. Once a PDX tumor "takes" and starts to grow, it can be split up into many more tumors and each could in theory be tested in a mini "clinical trial" in the lab using different drugs. #lcsm |
| #LCSM Chat @lcsmchat RT @Notmadscientist: The mouse represents a closer environment to where the original tumor was in the body as compared to a petri dish. The mouse is far from perfect though #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: EGFR Resisters also have a project to create cancer models. So does the Borad Institute--part of their "Rare Cancers Dependencies Map" project. #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: @cancertrek @Notmadscientist They better reflect the environment of human tumors with lots of other cells and physiological factors interacting. Can also be used in setting of an intact immune system. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: The mouse represents a closer environment to where the original tumor was in the body as compared to a petri dish. The mouse is far from perfect though #LCSM |
| Anita Figueras @scifiknitter RT @Notmadscientist: The mouse represents a closer environment to where the original tumor was in the body as compared to a petri dish. The mouse is far from perfect though #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: @cancertrek @Notmadscientist They better reflect the environment of human tumors with lots of other cells and physiological factors interacting. Can also be used in setting of an intact immune system. #lcsm |
| Deb Smith 🌻🟧 @debsmithbeach RT @BrendonStilesMD: T2. A great read for those of you who haven't come across it. Fortunately times have changed and consent is required, along with some description of potential uses. #lcsm https://t.co/mkiPimK5qW |
| Janet Freeman-Daily @JFreemanDaily Cancer drugs are usually tested against mouse models. in early 2017, ROS1 had ONE mouse model. Given that the ROS1 gene can fuse with over 20 different genes, this is a problem. We don't know if the drug works for other pairings. #LCSM |
| Janet Freeman-Daily @JFreemanDaily T4: What are the advantages and disadvantages of the different types of cancer models? #LCSM (we've kinda anticipated this already) |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Cancer drugs are usually tested against mouse models. in early 2017, ROS1 had ONE mouse model. Given that the ROS1 gene can fuse with over 20 different genes, this is a problem. We don't know if the drug works for other pairings. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Cancer drugs are usually tested against mouse models. in early 2017, ROS1 had ONE mouse model. Given that the ROS1 gene can fuse with over 20 different genes, this is a problem. We don't know if the drug works for other pairings. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: T4: T4: What are the advantages and disadvantages of the different types of cancer models? #LCSM (we've kinda anticipated this already) |
| Janet Freeman-Daily @JFreemanDaily T4: Cell lines are particularly useful for high-throughput screening. A robot selects the cell line and distributes it into lots of small containers. Another robot then selects drugs and mixes them into various combos and concentrations. #LCSM |
 | Showtime @withspin RT @BrendonStilesMD: Here is a good review from 2015.https://t.co/pQlHfv6OlM Science is still evolving. #lcsm |
| Adam Marcus PhD @AdamMarcusPhD T4: Cell lines are much easier, less costly, and quicker to manipulate (remove genes, insert genes) than a mouse model or PDX model. However mouse models are probably more like the actual disease #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: T4: T4: Cell lines are particularly useful for high-throughput screening. A robot selects the cell line and distributes it into lots of small containers. Another robot then selects drugs and mixes them into various combos and concentrations. #LCSM |
| Matthew Katz, MD 🟦 @subatomicdoc RT @BrendonStilesMD: @cancertrek @Notmadscientist They better reflect the environment of human tumors with lots of other cells and physiological factors interacting. Can also be used in setting of an intact immune system. #lcsm |
| Showtime @withspin RT @BrendonStilesMD: T3. For us, we take tumors directly from consented patients in the OR in a special solution and then implant small pieces into the sides of immune suppressed mice. We have a core facility that can do it for almost any tumor. #lcsm |
| Matthew Katz, MD 🟦 @subatomicdoc RT @JFreemanDaily: T4: T4: What are the advantages and disadvantages of the different types of cancer models? #LCSM (we've kinda anticipated this already) |
| Janet Freeman-Daily @JFreemanDaily A third robot combines the drugs with the cell lines, and later evaluates whether the cells grew or died. Must faster than combining drugs and cell lines by hand. #LCSM |
| Anita Figueras @scifiknitter RT @JFreemanDaily: T4: T4: Cell lines are particularly useful for high-throughput screening. A robot selects the cell line and distributes it into lots of small containers. Another robot then selects drugs and mixes them into various combos and concentrations. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: T4: T4: What are the advantages and disadvantages of the different types of cancer models? #LCSM (we've kinda anticipated this already) |
| Faces of Lung Cancer @LungCancerFaces RT @JFreemanDaily: T4: T4: What are the advantages and disadvantages of the different types of cancer models? #LCSM (we've kinda anticipated this already) |
| Adam Marcus PhD @AdamMarcusPhD T4: In the lab we try to take as comprehensive approach as possible and have about 25 lung cancer cell lines, 10 organoids, and 2 genetic lung cancer models; though it is not financially feasible to use all #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: T4: T4: Cell lines are particularly useful for high-throughput screening. A robot selects the cell line and distributes it into lots of small containers. Another robot then selects drugs and mixes them into various combos and concentrations. #LCSM |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T4: T4: Cell lines are much easier, less costly, and quicker to manipulate (remove genes, insert genes) than a mouse model or PDX model. However mouse models are probably more like the actual disease #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: A third robot combines the drugs with the cell lines, and later evaluates whether the cells grew or died. Must faster than combining drugs and cell lines by hand. #LCSM |
| Janet Freeman-Daily @JFreemanDaily Mouse models have the disadvantage that they eventually incorporate mouse tissue into the model (blood vessels, immune cells, etc). Both cell lines and mouse models eventually diverge from the human cancer. #LCSM |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T4: T4: In the lab we try to take as comprehensive approach as possible and have about 25 lung cancer cell lines, 10 organoids, and 2 genetic lung cancer models; though it is not financially feasible to use all #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Mouse models have the disadvantage that they eventually incorporate mouse tissue into the model (blood vessels, immune cells, etc). Both cell lines and mouse models eventually diverge from the human cancer. #LCSM |
 | Ginger Riley ~Eternal Optimist~ @gingerly21 RT @NCICancerStats: Lung cancer is the leading cause of death for both men and women in the United States. Watch our DYK video for more info: https://t.co/MnrkjeW1f2 #LCAM #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T4: T4: Cell lines are much easier, less costly, and quicker to manipulate (remove genes, insert genes) than a mouse model or PDX model. However mouse models are probably more like the actual disease #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: A third robot combines the drugs with the cell lines, and later evaluates whether the cells grew or died. Must faster than combining drugs and cell lines by hand. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T4: T4: In the lab we try to take as comprehensive approach as possible and have about 25 lung cancer cell lines, 10 organoids, and 2 genetic lung cancer models; though it is not financially feasible to use all #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Mouse models have the disadvantage that they eventually incorporate mouse tissue into the model (blood vessels, immune cells, etc). Both cell lines and mouse models eventually diverge from the human cancer. #LCSM |
| Brendon Stiles @BrendonStilesMD T4. Most important thing to realize is that there is no "perfect" model. All can be used to answer different, important questions and many can be used in a stepwise approach to tackle a scientific hypothesis. #lcsm |
| Janet Freeman-Daily @JFreemanDaily If the patient's hospital is not making cancer models, it's up to the patient to find a study to which their tissues can be donated. Not a lot of options at the moment, but some do exist. #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: T4. Most important thing to realize is that there is no "perfect" model. All can be used to answer different, important questions and many can be used in a stepwise approach to tackle a scientific hypothesis. #lcsm |
| Anita Figueras @scifiknitter RT @JFreemanDaily: Mouse models have the disadvantage that they eventually incorporate mouse tissue into the model (blood vessels, immune cells, etc). Both cell lines and mouse models eventually diverge from the human cancer. #LCSM |
| Anita Figueras @scifiknitter RT @BrendonStilesMD: T4. Most important thing to realize is that there is no "perfect" model. All can be used to answer different, important questions and many can be used in a stepwise approach to tackle a scientific hypothesis. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: T4. Most important thing to realize is that there is no "perfect" model. All can be used to answer different, important questions and many can be used in a stepwise approach to tackle a scientific hypothesis. #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: If the patient's hospital is not making cancer models, it's up to the patient to find a study to which their tissues can be donated. Not a lot of options at the moment, but some do exist. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: If the patient's hospital is not making cancer models, it's up to the patient to find a study to which their tissues can be donated. Not a lot of options at the moment, but some do exist. #LCSM |
| Anita Figueras @scifiknitter RT @JFreemanDaily: If the patient's hospital is not making cancer models, it's up to the patient to find a study to which their tissues can be donated. Not a lot of options at the moment, but some do exist. #LCSM |
| Janet Freeman-Daily @JFreemanDaily @BrendonStilesMD I'm thoroughly impressed. I have a hard time finding resources during a chat! It's hard enough keeping up with the discussion. I blame chemo brain. #LCSM |
| Janet Freeman-Daily @JFreemanDaily Last topic T5 is on the way … #LCSM |
| Brendon Stiles @BrendonStilesMD Have to drop off but thanks for organizing this chat! Really important topic. And critical for patients to understand how and why of science so that they can communicate their questions, needs, and ideas to research community. #lcsm |
| Janet Freeman-Daily @JFreemanDaily T5: Where can we learn more about cancer models and support research with cancer models? #LCSM |
| #LCSM Chat @lcsmchat RT @BrendonStilesMD: Have to drop off but thanks for organizing this chat! Really important topic. And critical for patients to understand how and why of science so that they can communicate their questions, needs, and ideas to research community. #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: T5: T5: Where can we learn more about cancer models and support research with cancer models? #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: @BrendonStilesMD I'm thoroughly impressed. I have a hard time finding resources during a chat! It's hard enough keeping up with the discussion. I blame chemo brain. #LCSM |
| Bob Steele @steele_bob RT @JFreemanDaily: T5: T5: Where can we learn more about cancer models and support research with cancer models? #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @BrendonStilesMD: Have to drop off but thanks for organizing this chat! Really important topic. And critical for patients to understand how and why of science so that they can communicate their questions, needs, and ideas to research community. #lcsm |
| Matthew Katz, MD 🟦 @subatomicdoc RT @JFreemanDaily: T5: T5: Where can we learn more about cancer models and support research with cancer models? #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: T5: T5: Where can we learn more about cancer models and support research with cancer models? #LCSM |
| Janet Freeman-Daily @JFreemanDaily There's a long (and somewhat complicated) blog about cancer models on the ROS1 Cancer website. https://t.co/jau1IJWUyU #LCSM |
| Janet Freeman-Daily @JFreemanDaily @BrendonStilesMD Thanks for joining! You shared a lot of great info. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: There's a long (and somewhat complicated) blog about cancer models on the ROS1 Cancer website. https://t.co/jau1IJWUyU #LCSM |
| Matthew Katz, MD 🟦 @subatomicdoc RT @JFreemanDaily: There's a long (and somewhat complicated) blog about cancer models on the ROS1 Cancer website. https://t.co/jau1IJWUyU #LCSM |
| Faces of Lung Cancer @LungCancerFaces RT @JFreemanDaily: T5: T5: Where can we learn more about cancer models and support research with cancer models? #LCSM |
| Anita Figueras @scifiknitter RT @JFreemanDaily: There's a long (and somewhat complicated) blog about cancer models on the ROS1 Cancer website. https://t.co/jau1IJWUyU #LCSM |
| Bob Steele @steele_bob T1-T5: I'm likely to have MANY questions re cancer models. Any volunteers I can follow up with? #lcsm |
| Janet Freeman-Daily @JFreemanDaily Here is the ROS1 Cancer Model Project study for PDX mice. https://t.co/hkijnAR7MX #LCSM |
| Adam Marcus PhD @AdamMarcusPhD T5: Most academic cancer centers (and other research institutes as well) will have research to generate and use cancer models. #LCSM |
| Janet Freeman-Daily @JFreemanDaily @tilting Yes, at the moment. We don't a good model of a living immune system. However, GEM mice are becoming more popular for this--for instance, delete the right segment of EGFR gene in a GEM mouse and you have a good model for testing immunotherapy on EGFR Exon 19. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: There's a long (and somewhat complicated) blog about cancer models on the ROS1 Cancer website. https://t.co/jau1IJWUyU #LCSM |
 | Paula A @paulalv RT @JFreemanDaily: There's a long (and somewhat complicated) blog about cancer models on the ROS1 Cancer website. https://t.co/jau1IJWUyU #LCSM |
| #LCSM Chat @lcsmchat RT @steele_bob: T1-T5: T1-T5: I'm likely to have MANY questions re cancer models. Any volunteers I can follow up with? #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Here is the ROS1 Cancer Model Project study for PDX mice. https://t.co/hkijnAR7MX #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: Here is the ROS1 Cancer Model Project study for PDX mice. https://t.co/hkijnAR7MX #LCSM |
| #LCSM Chat @lcsmchat RT @Notmadscientist: T5: T5: Most academic cancer centers (and other research institutes as well) will have research to generate and use cancer models. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: @tilting Yes, at the moment. We don't a good model of a living immune system. However, GEM mice are becoming more popular for this--for instance, delete the right segment of EGFR gene in a GEM mouse and you have a good model for testing immunotherapy on EGFR Exon 19. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @Notmadscientist: T5: T5: Most academic cancer centers (and other research institutes as well) will have research to generate and use cancer models. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: @tilting Yes, at the moment. We don't a good model of a living immune system. However, GEM mice are becoming more popular for this--for instance, delete the right segment of EGFR gene in a GEM mouse and you have a good model for testing immunotherapy on EGFR Exon 19. #LCSM |
| Janet Freeman-Daily @JFreemanDaily @Notmadscientist Although most cancer centers tend to specialize in a few cancers. No center makes models of ALL cancers. Helps to know where to go. #LCSM |
| Janet Freeman-Daily @JFreemanDaily The NCI has a Human Cancer Models Initiative. https://t.co/0XrEQQetsO #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: @Notmadscientist Although most cancer centers tend to specialize in a few cancers. No center makes models of ALL cancers. Helps to know where to go. #LCSM |
| Bob Steele @steele_bob RT @JFreemanDaily: The NCI has a Human Cancer Models Initiative. https://t.co/0XrEQQetsO #LCSM |
| KC Dill @kasedill As an elementary student I participated in the send a mouse to college program.. Now I understand the need for so many specimens #lcsm |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: The NCI has a Human Cancer Models Initiative. https://t.co/0XrEQQetsO #LCSM |
| Janet Freeman-Daily @JFreemanDaily https://t.co/d8LItxrkAY has a portal through which patients can volunteer to donate certain cancer tissues to make models at @broadinstitute https://t.co/oE5hvbEnpn #LCSM |
| Anita Figueras @scifiknitter Here is the study that is seeking to create models EGFR+ lung cancer. Focus: Osimertinib resistance and Exon 20 https://t.co/RptKCj4PPm #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: @Notmadscientist Although most cancer centers tend to specialize in a few cancers. No center makes models of ALL cancers. Helps to know where to go. #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: The NCI has a Human Cancer Models Initiative. https://t.co/0XrEQQetsO #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @kasedill: As an elementary student I participated in the send a mouse to college program.. Now I understand the need for so many specimens #lcsm |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD RT @JFreemanDaily: https://t.co/d8LItxrkAY has a portal through which patients can volunteer to donate certain cancer tissues to make models at @broadinstitute https://t.co/oE5hvbEnpn #LCSM |
| Anita Figueras @scifiknitter RT @JFreemanDaily: @tilting Yes, at the moment. We don't a good model of a living immune system. However, GEM mice are becoming more popular for this--for instance, delete the right segment of EGFR gene in a GEM mouse and you have a good model for testing immunotherapy on EGFR Exon 19. #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: https://t.co/d8LItxrkAY has a portal through which patients can volunteer to donate certain cancer tissues to make models at @broadinstitute https://t.co/oE5hvbEnpn #LCSM |
| #LCSM Chat @lcsmchat RT @scifiknitter: Here is the study that is seeking to create models EGFR+ lung cancer. Focus: Here is the study that is seeking to create models EGFR+ lung cancer. Focus: Osimertinib resistance and Exon 20 https://t.co/RptKCj4PPm #LCSM |
| Anita Figueras @scifiknitter RT @JFreemanDaily: @Notmadscientist Although most cancer centers tend to specialize in a few cancers. No center makes models of ALL cancers. Helps to know where to go. #LCSM |
| Anita Figueras @scifiknitter RT @JFreemanDaily: The NCI has a Human Cancer Models Initiative. https://t.co/0XrEQQetsO #LCSM |
| Janet Freeman-Daily @JFreemanDaily Jackson Labs, which makes PDX mice, has information on its website. https://t.co/91OJsAGgil #LCSM |
| Anita Figueras @scifiknitter RT @JFreemanDaily: https://t.co/d8LItxrkAY has a portal through which patients can volunteer to donate certain cancer tissues to make models at @broadinstitute https://t.co/oE5hvbEnpn #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Jackson Labs, which makes PDX mice, has information on its website. https://t.co/91OJsAGgil #LCSM |
| Adam Marcus PhD @AdamMarcusPhD Logging off now. If anyone has additional questions, happy to help! #LCSM |
| Janet Freeman-Daily @JFreemanDaily Champions Oncology, which also makes PDX mice, has information on their site as well. https://t.co/ca8es2e5uy #LCSM |
| Bob Steele @steele_bob I have a good research mouse story. #lcsm |
| Janet Freeman-Daily @JFreemanDaily We’re in our final minutes - closing thoughts? #LCSM |
| #LCSM Chat @lcsmchat RT @Notmadscientist: Logging off now. If anyone has additional questions, happy to help! #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: Champions Oncology, which also makes PDX mice, has information on their site as well. https://t.co/ca8es2e5uy #LCSM |
| Bob Steele @steele_bob RT @Notmadscientist: Logging off now. If anyone has additional questions, happy to help! #LCSM |
| Janet Freeman-Daily @JFreemanDaily @steele_bob Ask me! If I don't know, I'll find out. #LCSM |
| Matthew Katz, MD 🟦 @subatomicdoc RT @JFreemanDaily: Jackson Labs, which makes PDX mice, has information on its website. https://t.co/91OJsAGgil #LCSM |
| Janet Freeman-Daily @JFreemanDaily @steele_bob A story you tell to research mice at bedtime? ;) #LCSM |
| #LCSM Chat @lcsmchat RT @JFreemanDaily: We’re in our final minutes - closing thoughts? #LCSM |
| Timothy Craig Allen, MD, JD, FCAP @TimAllenMDJD Great educational #lcsm session. Thanks for discussing this important research tool! |
| Denise Cutlip @dennycee Trying to keep up with links and chat. Excellent education tonight thanks. My brain is full. #lcsm |
| #LCSM Chat @lcsmchat Thank you @JFreemanDaily for tackling this topic tonight! #LCSM |
| Janet Freeman-Daily @JFreemanDaily Thanks for joining #LCSM Chat! If you found this chat topic helpful, let us know. Maybe we can start structuring "tweetorials" for future chats. #LCSM |
 | Karen Friedberg @4131penny RT @cancertrek: Just hit my 6-year #lungcancer anniversary yesterday. Aiming for 7 now, and planning on 8 after that. Still trying to help as many others sharing this journey as I can along the way. #lcsm #LCAM #MovingForward #neverstop |
 | Jeff Garner 🇬🇧🇨🇦🎗 @McGuffieLad RT @LCAM_org: When Dawn Horner was diagnosed with stage IV #lungcancer, she was initially told that she would be put on palliative care. However, she found a second opinion and is now enjoying life with a sense of profound gratitude. #LCSM #LCAM #HopeLives https://t.co/xZtJKD1Ytl https://t.co/rqwlZb6NHb |
| Anita Figueras @scifiknitter Great chat @JFreemanDaily. In learned a lot and will share the transcript with the @EGFRResisters. #LCSM |
| Bob Steele @steele_bob @JFreemanDaily @steele_bob LOL. I tried to make delivery of 3 boxes of mice to a research lab. The joke was on me. #lcsm |
| Bob Steele @steele_bob RT @TimAllenMDJD: Great educational #lcsm session. Thanks for discussing this important research tool! |
| Deb Smith 🌻🟧 @debsmithbeach RT @scifiknitter: Here is the study that is seeking to create models EGFR+ lung cancer. Focus: Here is the study that is seeking to create models EGFR+ lung cancer. Focus: Osimertinib resistance and Exon 20 https://t.co/RptKCj4PPm #LCSM |
| Bob Steele @steele_bob Thanks everyone. Lot's to read, watch & learn. Look forward to seeing you in 2 weeks. Good night. #lcsm |
| Bob Steele @steele_bob RT @scifiknitter: Great chat @JFreemanDaily. In learned a lot and will share the transcript with the @EGFRResisters. #LCSM |
| Janet Freeman-Daily @JFreemanDaily Transcript for tonight’s #LCSM Chat “What’s a cancer model, and why should I care?” is available at https://t.co/Tet0QKsImR #LCSM |
| Showtime @withspin RT @JFreemanDaily: There's a long (and somewhat complicated) blog about cancer models on the ROS1 Cancer website. https://t.co/jau1IJWUyU #LCSM |
| Faces of Lung Cancer @LungCancerFaces RT @JFreemanDaily: Transcript for tonight’s #LCSM Chat “What’s a cancer model, and why should I care?” is available at https://t.co/Tet0QKsImR #LCSM |
 | OurWarOnCancer @OurWarOnCancer RT @OurWarOnCancer: #LungCancerAwarenessMonth #433aday #lcsm #lungcancer #1cancerkiller #LCAM We must have increased research funding 2 save 160,000 lives a year & save 1.7 million lives worldwide. If U have lungs U can get #lungcancer @Surgeon_General https://t.co/ELAihoK5Pa |
| OurWarOnCancer @OurWarOnCancer RT @OurWarOnCancer: LUNG CANCER is the #1Cancer killer WORLDWIDE. 1.7 Million deaths year. What are we doing to develop better early detection, treatments and cures? #LungCancerAwarenessMonth #LCAM #LCSM We need our tech titans to help lead the way @billgates @gatesfoundation @gateshealth @tim_cook https://t.co/7d7FE0kpHb |
| OurWarOnCancer @OurWarOnCancer RT @OurWarOnCancer: https://t.co/Mlk3xYxUlu #433aday #lcsm #lungcancer #1cancerkiller #LCAM We must increase research funding 2 save 160,000 lives a year & save 1.7 million lives worldwide. If U have lungs U can get #lungcancer @Surgeon_General |
| Bob Steele @steele_bob RT @JFreemanDaily: Transcript for tonight’s #LCSM Chat “What’s a cancer model, and why should I care?” is available at https://t.co/Tet0QKsImR #LCSM |
| Janet Freeman-Daily @JFreemanDaily FYI, here's what a #ROS1 cell line looks like under a microscope! @ros1cancer #LCSM https://t.co/0KgsNgFkFz |
 | Nadia Prescott @emergingexec RT @LCAorg: Only two days left! For every #tALKpositiveNSCLC hashtag used in November, @TakedaOncology will donate $10 to support our work. Making a difference is just that easy! Take action today! #LCAM #LCSM |
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