#NephJC Transcript
Healthcare social media transcript of the #NephJC hashtag.
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See #NephJC Influencers/Analytics.
| Profile | Tweet |
|---|---|
 | Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 I stand with @nwkidney + @DCI_Dialysis: I oppose the #Dialysis PATIENTS Demonstration Act Read why below #nephJC #esrd #nephrology https://t.co/aTKCBeJZu6 |
 | Nephrology Journal Club @NephJC #NephJC chat tonight & tomorrow Summary https://t.co/oHuORfmKhO by @LangoteAmit Free full text via @JAMA_current https://t.co/OuyRcHdKNv |
 | Swapnil Hiremath @hswapnil@bsky.social @hswapnil RT @NephJC: #NephJC chat tonight & tomorrow Summary https://t.co/oHuORfmKhO by @LangoteAmit Free full text via @JAMA_current https://t.co/OuyRcHdKNv |
 | Anna Burgner MD MEHP @anna_burgner RT @NephJC: #NephJC chat tonight & tomorrow Summary https://t.co/oHuORfmKhO by @LangoteAmit Free full text via @JAMA_current https://t.co/OuyRcHdKNv |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @AJKDonline @Maximal_Change : Your blog makes a compelling argument for protocol biopsies Thanks for sharing #nephJC #nephrology https://t.co/2iVl82Uihy |
 | Rizwan Hamer @DrRHamer RT @NephJC: #NephJC chat tonight & tomorrow Summary https://t.co/oHuORfmKhO by @LangoteAmit Free full text via @JAMA_current https://t.co/OuyRcHdKNv |
| Nephrology Journal Club @NephJC #NephJC chat in under 2 hours Not too late to read the summary: https://t.co/oHuORfmKhO |
 | Nathaniel Reisinger @nephrothaniel RT @NephJC: #NephJC chat in under 2 hours Not too late to read the summary: https://t.co/oHuORfmKhO |
 | Joel M. Topf, MD FACP @kidney_boy Tonight on #NephJC we will be discussing this. See the summary at https://t.co/DSQSC5em9g https://t.co/j5MzQLC63B |
 | Francisco Fernandez @PsyVIDAS201718 RT @kidney_boy: Tonight on #NephJC we will be discussing this. See the summary at https://t.co/DSQSC5em9g https://t.co/j5MzQLC63B |
| Nephrology Journal Club @NephJC RT @kidney_boy: Tonight on #NephJC we will be discussing this. See the summary at https://t.co/DSQSC5em9g https://t.co/j5MzQLC63B |
 | Matthew Sparks, MD @Nephro_Sparks testing testing testing #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @tulunsokit 9pm EDT 30 min away #nephjc |
 | NBLU: Renal Leaders @NBLUniv RT @NephJC: #NephJC chat tonight & tomorrow Summary https://t.co/oHuORfmKhO by @LangoteAmit Free full text via @JAMA_current https://t.co/OuyRcHdKNv |
 | Mohammed Hamdi @mhamdi1986 Hello #nephjc |
| Mohammed Hamdi @mhamdi1986 I'm a first year internal medicine resident, at St. John Hospital and Medical Center in Michigan. #nephjc |
 | Penn Kidney @PennKidney RT @kidney_boy: Tonight on #NephJC we will be discussing this. See the summary at https://t.co/DSQSC5em9g https://t.co/j5MzQLC63B |
 | Mina @mina52926039 Hello everyone... My name is Mina, and I’m a transplant nephrology fellow at St. John hospital in Detroit. #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @Mina52926039 Hi Mina, thanks for joining #NephJC |
 | Joe Nowatzke @jnowatzke11 Hello. I'm a third year medical student, currently on my nephrology elective at St. John Hospital in Detroit. #nephjc |
| Mina @mina52926039 even though I’m doing transplant now I still think IgA nephrology has the coolest pathology #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @mhamdi1986 Hi Mohammed #NephJC 🤜🤛 |
| Matthew Sparks, MD @Nephro_Sparks @jnowatzke11 Nice 👍🏼I feel a St John take over #NephJC welcome |
 | Christina @xstina123 Hi! I'm Christina, a first year nephrology fellow at St. John Hospital in Detroit #nephjc |
| Matthew Sparks, MD @Nephro_Sparks Detroit Represent #NephJC https://t.co/HHhupBoLPy |
| Mina @mina52926039 ✊🏽 #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @xstina123 Is @kidney_boy setting up aliases?? Hi Christina #NephJC |
| Nephrology Journal Club @NephJC Testing testing, is anyone here? 9 minutes to #NephJC |
| Joel M. Topf, MD FACP @kidney_boy Running around like a chicken with his head cut off getting everyone set up #nephjc |
| Joel M. Topf, MD FACP @kidney_boy @NephJC STOP-IGA STP-IGA we are here #nephjc |
| Matthew Sparks, MD @Nephro_Sparks Nice job #NephJC https://t.co/HEBnOV255Z |
| Nephrology Journal Club @NephJC Does look like the Detroit crowd is all here! Hi Mina, Christina, Joe, Mohamed! #nephjc |
| Matthew Sparks, MD @Nephro_Sparks as usual @langoteamit has a nice summary over at https://t.co/Je0JyuktbH #nephjc |
| Joel M. Topf, MD FACP @kidney_boy For #NephJC here is the #VisualAbstract for STOP-IgA https://t.co/PQPVKx8H84 |
| Matthew Sparks, MD @Nephro_Sparks lets see if I can gather the @DukeKidney crowd for #NephJC @DanEdmonston @SirDurhamite @JohnMusgrove |
| Nephrology Journal Club @NephJC RT @kidney_boy: For #NephJC here is the #VisualAbstract for STOP-IgA https://t.co/PQPVKx8H84 |
| Nathaniel Reisinger @nephrothaniel RT @kidney_boy: For #NephJC here is the #VisualAbstract for STOP-IgA https://t.co/PQPVKx8H84 |
| Matthew Sparks, MD @Nephro_Sparks RT @kidney_boy: For #NephJC here is the #VisualAbstract for STOP-IgA https://t.co/PQPVKx8H84 |
| Matthew Sparks, MD @Nephro_Sparks @MohammadAlsawah @DukeKidney @DanEdmonston @SirDurhamite @JohnMusgrove Hey Mohammad,.. it was a great week. hope you are well #NephJC |
| Joel M. Topf, MD FACP @kidney_boy That graphic was done by the michaelangelo of #VisualAbstract's... @KidneyBea_n #NephJC |
| Amr Youssef @amryou277 Hello, I am a nephro fellow at St. John hospital. #nephjc | |
| Nephrology Journal Club @NephJC It's 9 pm Welcome to the 3rd time we are discussing the second most common glomerular disease on a #NephJC chat |
 | Eleanor Lederer @EleanorLederer #NephJC Are we starting? |
| Joel M. Topf, MD FACP @kidney_boy @AmrYou277 welcome to your first #nephjc |
| Nephrology Journal Club @NephJC @EleanorLederer we are! welcome to #NephJC #POTASN! |
| Joel M. Topf, MD FACP @kidney_boy Hail to the chief ! @EleanorLederer #nephjc |
| Nephrology Journal Club @NephJC Please introduce yourself & declare any CoI (conflicts of interest) We especially want to hear from lurking students & patients #NephJC |
| Matthew Sparks, MD @Nephro_Sparks Matt Sparks here. @DukeKidney APD @KIDNEYcon Edu Dir. @NephMadness co-creator #nephjc |
| Nephrology Journal Club @NephJC Your host tonight is Swapnil Hiremath @hswapnil from @OttawaHospital #NephJC |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @gratefull080504 is here on a Airplane flight tonight It nothing else, you can't call me dedicated to #nephJC |
| Swapnil Hiremath @hswapnil@bsky.social @hswapnil Swapnil Hiremath, nephrologist from @OttawaRenal Will keep personal opinions here #NephJC https://t.co/IFUn41pmrZ |
 | Bea Concepcion @KidneyBea_n Hi everyone! Bea Concepcion @VUMCKidney #NSMC no COI. #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @gratefull080504 Kevin! how are you? always traveling. #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @KidneyBea_n @VUMCKidney Hi Bea #nephjc |
 | Roger Rodby @NephRodby Roger Rodby, Rush Chicago, no COI except never used steroids for IgA #NephJC |
| Nephrology Journal Club @NephJC Thanks for joining - Kevin, Bea, Eleanor, Matt and Joel w/ the Detroit gang #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 COI: Protalix, Horizon Pharma, @TapCloudHealth #nephJC |
 | Edgar V. Lerma 🇵🇭 @edgarvlermamd Edgar Lerma, Chicago-based Nephrologist #NephJC https://t.co/EqSRE4wP71 |
| Matthew Sparks, MD @Nephro_Sparks @edgarvlermamd Hi Edgar #nephjc |
| Nephrology Journal Club @NephJC #NephJC recommends using @TweetChat or @tchatio to make sure you see all the convo eg go to https://t.co/4zRxyflhEJ |
| Matthew Sparks, MD @Nephro_Sparks @hswapnil @OttawaRenal Swap has opinions.... never #nephjc |
| Roger Rodby @NephRodby Hey Bea, Matt, Swap, Joel #NephJC |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @Nephro_Sparks Hi @Nephro_Sparks Yes I am! The life of a consultant #nephJC |
| Nephrology Journal Club @NephJC Hi Edgar, Roger & Tulun. A Global chat already... #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @tulunsokit Hi Tulun #nephjc |
| Joel M. Topf, MD FACP @kidney_boy COI: I own a massive prednisone plant. So 'roids for everyone #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @NephRodby Hey Roger. How is Chi town and #RushRenalRules #nephjc |
 | TEJAS PATEL MD, FACP, FASN @GenNextMD Hello everyone, Tejas Patel Faculty from Mount Sinai St. Luke's #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @GenNextMD Hi Tejas #nephjc |
 | Gates Colbert, MD @DoctorGates Dallas Nephrologist. ACEI / ARB are a Nephrologist's scalpel. #IgA #nephjc |
 | Scherly Leon, MD @SLeonMD Scherly Leon, nephrologist in NYC. #nephjc |
| Nephrology Journal Club @NephJC @GenNextMD Hi Tejas, welcome back! #nephjc |
| Eleanor Lederer @EleanorLederer #NephJC I for one would really like 4th to know what to do with IgAN. So many con chi lucting reports. |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @EleanorLederer @Nephro_Sparks @EleanorLederer : When you are involved with #clinicaltrials, you see a lot of airports! I was in Louisville about a month ago #nephJC |
| Nephrology Journal Club @NephJC Great to see you guys - Scerly and Gates (nice job on the newsletters Gates) #nephjc |
| Nephrology Journal Club @NephJC We will be discussing the @JAMA_current RCT TESTING (Therapeutic Evaluation of Steroids in IgA Nephropathy Global) #NephJC |
| mohammad alsawah @mohammadalsawah #nephjc |
| TEJAS PATEL MD, FACP, FASN @GenNextMD Hi Matt @Nephro_Sparks Good evening #nephJC https://t.co/DiF7TaQKzK |
| Scherly Leon, MD @SLeonMD RT @kidney_boy: For #NephJC here is the #VisualAbstract for STOP-IgA https://t.co/PQPVKx8H84 |
 | Franklin Loachamin @FranLoachamin #NephJC hey guys good night . Franklin Loachamin. Quito Ecuador. Ped neph. NO COI |
| Nephrology Journal Club @NephJC Full text link (thanks! @JAMA_current) : https://t.co/OuyRcHdKNv #NephJC |
 | Michelle Rheault @rheault_m @NephJC Michelle Rheault, Ped Neph UMN. COI in bio. Just home from school supply shopping so mind a bit frazzled. #NephJC |
| Nathaniel Reisinger @nephrothaniel Nathaniel Reisinger, NSMC Intern #NephJC |
| Scherly Leon, MD @SLeonMD RT @kidney_boy: Tonight on #NephJC we will be discussing this. See the summary at https://t.co/DSQSC5em9g https://t.co/j5MzQLC63B |
| Michelle Rheault @rheault_m RT @NephJC: We will be discussing the @JAMA_current RCT TESTING (Therapeutic Evaluation of Steroids in IgA Nephropathy Global) #NephJC |
 | rob @renalpolitics #nephjc howdy folks, Rob Rope, new nephrolist in OR, trying to follow along, no COI |
| Joel M. Topf, MD FACP @kidney_boy @MohammadAlsawah Thanks for coming! #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @EleanorLederer Whoa a visit from the president... we all need to be on our best behaviour ... looking at Roger and Joel #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @kidney_boy Not for me Only on 5mg prednisone #nephJC |
| Matthew Sparks, MD @Nephro_Sparks @renalpolitics Hey Rob #nephjc |
| Nephrology Journal Club @NephJC Nathaniel, Michelle and Franklin! welcome - and nice to see Rob, hows the new job? #nephjc |
 | Dr. Jordan Weinstein @drjjw #NephJC Hi all |
| Matthew Sparks, MD @Nephro_Sparks @nephrothaniel Nathaniel #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @drjjw Hey Jordan11 #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @rheault_m @NephJC Miss those days! #nephJC |
| Eleanor Lederer @EleanorLederer #nephJC whoa that was supposed to be conflicting, not that bizarre string of letters |
| Nephrology Journal Club @NephJC And an excellent summary for #NephJC from @LangoteAmit https://t.co/oHuORfmKhO |
| Nephrology Journal Club @NephJC T0 How do you Rx IgA? If not crescentic, GFR > 30, proteinuria > 1 g/day - Supportive (?BP target, ?dual RAAS) - steroids - more? #NephJC |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 Looking forward to the discussion #nephJC https://t.co/u8iJX5Iyes |
| Matthew Sparks, MD @Nephro_Sparks @FranLoachamin Hey Fran #nephjc |
| Joel M. Topf, MD FACP @kidney_boy My plans to adrenally suppress the world have been foiled RT @Nephro_Sparks: @renalpolitics Hey Rob #nephjc |
| Nephrology Journal Club @NephJC @drjjw Nice to see you Jordan! #nephjc |
| rob @renalpolitics #nephjc -- new job is good, very slow in clinic, lots of good cases though, twiddling thumbs waiting for HD unit accredidation |
| Nephrology Journal Club @NephJC RT @Nephro_Sparks: @EleanorLederer Whoa a visit from the president... we all need to be on our best behaviour ... looking at Roger and Joel #nephjc |
 | J. Brian Byrd Lab @thebyrdlab @Nephro_Sparks @NephRodby Hi Roger, Matt, Bea, Swap, Joel. Lurking this evening. #NephJC |
| Scherly Leon, MD @SLeonMD @MohammadAlsawah Hi! It has been raining but good. #nephjc |
| Anna Burgner MD MEHP @anna_burgner Late to the party, but I'm here! Clinical nephrologist @VUMCKidney, no coi #NephJC |
| Nephrology Journal Club @NephJC @thebyrdlab @Nephro_Sparks @NephRodby always glad to have you Brian! Honorary Nephrologist #nephjc |
| Nephrology Journal Club @NephJC @anna_burgner @VUMCKidney glad you could make it Anna! #nephjc |
| J. Brian Byrd Lab @thebyrdlab Thanks! https://t.co/oxjwdJfMVG |
| Eleanor Lederer @EleanorLederer #nephJC I am intrinsically a conservative MD. Maybe too conservative. The only time I use immunos is with RPGN complicating IgAN. |
| Joel M. Topf, MD FACP @kidney_boy I have had good outcomes (resolution of proteinuria) with 1 mg/kg of prednisone. #nephjc |
| Swapnil Hiremath @hswapnil@bsky.social @hswapnil RT @NephJC: T0 How do you Rx IgA? If not crescentic, GFR > 30, proteinuria > 1 g/day - Supportive (?BP target, ?dual RAAS) - steroids - more? #NephJC |
| Gates Colbert, MD @DoctorGates @NephJC Always ACEI/ARB (but not dual!) as BP will tolerate. Steroids if >1g proteinuria, monitor sx. Always can go LOWER on steroids. #NephJC |
| Mina @mina52926039 Heard it was the only indication for dual RAAS but never had the opportunity to treat these guys #nephjc |
| Nephrology Journal Club @NephJC RT @EleanorLederer: #nephJC I am intrinsically a conservative MD. Maybe too conservative. The only time I use immunos is with RPGN complicating IgAN. |
| TEJAS PATEL MD, FACP, FASN @GenNextMD RAAS +/- steroid...Not dual RAAS blockers #COOPERATIVE #nephJC https://t.co/B4M0QAbW8l |
| rob @renalpolitics @NephJC #nephJC, this is timely, got to meet J Floege a few weeks ago as came for talk. very nice, brilliant |
| TEJAS PATEL MD, FACP, FASN @GenNextMD RT @EleanorLederer: #nephJC I am intrinsically a conservative MD. Maybe too conservative. The only time I use immunos is with RPGN complicating IgAN. |
| Nephrology Journal Club @NephJC RT @GenNextMD: RAAS +/- steroid...Not dual RAAS blockers #COOPERATIVE #nephJC https://t.co/B4M0QAbW8l |
| Gates Colbert, MD @DoctorGates Its are usually not pleased after you put them through a biopsy and then tell them "No treatment, just keep on Lisinopril forever" #nephjc |
| Nephrology Journal Club @NephJC RT @DoctorGates: @NephJC Always ACEI/ARB (but not dual!) as BP will tolerate. Steroids if >1g proteinuria, monitor sx. Always can go LOWER on steroids. #NephJC |
| Roger Rodby @NephRodby I have been so reluctant to use steroids, bc IgA is chronic dz and steroids finite #NephJC |
| Gates Colbert, MD @DoctorGates Pts are usually not pleased after you put them through a biopsy and then tell them "No treatment, just keep on Lisinopril forever" #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 Can you predict the 30% of the population who will progress to #ESRD ? #nephJC |
| Matthew Sparks, MD @Nephro_Sparks sometimes see patients with relatively fast rising creat. biopsy with few crescents/none (sample error) give steroids in this case #nephjc |
| Nephrology Journal Club @NephJC There seem to be lot of steroid users here, except Profs Rodby & Lederer? #nephjc |
| Nathaniel Reisinger @nephrothaniel RT @NephRodby: I have been so reluctant to use steroids, bc IgA is chronic dz and steroids finite #NephJC |
| Nephrology Journal Club @NephJC @Nephro_Sparks that makes sense, clinically RPGN #nephjc |
| Joel M. Topf, MD FACP @kidney_boy RT @NephRodby: I have been so reluctant to use steroids, bc IgA is chronic dz and steroids finite #NephJC |
| Nephrology Journal Club @NephJC RT @NephRodby: I have been so reluctant to use steroids, bc IgA is chronic dz and steroids finite #NephJC |
| Matthew Sparks, MD @Nephro_Sparks if 1 g/proteinuria and stable creat... no steroids just RAASi #nephjc |
| Nephrology Journal Club @NephJC @rafidah72 @tulunsokit Hi Rafidah! Welcome to #NephJC |
| Roger Rodby @NephRodby If proliferative outside mesangium then OK, but only mesangial? hard to see how that helps #NephJC |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 How does biopsy guide treatment and intervention? #nephJC |
| rob @renalpolitics #nephjc - favor aggressive supportive care - great BP control, RAASi, eat well, etc. |
| Franklin Loachamin @FranLoachamin RT @EleanorLederer: #nephJC I am intrinsically a conservative MD. Maybe too conservative. The only time I use immunos is with RPGN complicating IgAN. |
| Nephrology Journal Club @NephJC RT @NephRodby: If proliferative outside mesangium then OK, but only mesangial? hard to see how that helps #NephJC |
| Nephrology Journal Club @NephJC RT @renalpolitics: #nephjc - favor aggressive supportive care - great BP control, RAASi, eat well, etc. |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 does that include exercise, lose weight, etc. ? #nephJC https://t.co/w2uLrIj4Yv |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd IgA Nephropathy from @CJASN #Nephpearls #NephJC 👉🏼 https://t.co/c9g9QUqr5u https://t.co/A1oUocPWkU |
| Nephrology Journal Club @NephJC @gratefull080504 helps to determine chronicity (fibrosis); if crescents ++ more likely to treat aggressively #nephjc |
| Roger Rodby @NephRodby I hate the side effects of steroids so I find reasons not to use them for IgA #NephJC |
| Matthew Sparks, MD @Nephro_Sparks @gratefull080504 combo of clinical presentation and path. Can use either in isolation #nephjc |
| Nephrology Journal Club @NephJC Background: mostly described in the Lv et al @JASN_News SR https://t.co/FAKfdIrYRe #nephJC Steroids likely work, but data not great https://t.co/W1lQgZDtja |
| Franklin Loachamin @FranLoachamin Supportive #NephJc https://t.co/oH54xIz9I3 |
| Joel M. Topf, MD FACP @kidney_boy I just can't sit back with a rising creatinine and 2 grams of protein and just refill the lisinopril. #nephjc |
| Roger Rodby @NephRodby But I think I am ignoring decent data and letting my bias control me #NephJC |
| Swapnil Hiremath @hswapnil@bsky.social @hswapnil @NephRodby I am on #TeamRodby tonight Don't like steroids Only use if MCD + IgA or RPGN #NephJC |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 The patients in the JAMA look very healthy compared to US population I wonder if that contributed to results as much as treatment #nephJC |
| Matthew Sparks, MD @Nephro_Sparks agree 👇 #NephJC https://t.co/LtJU9uAyaC |
| TEJAS PATEL MD, FACP, FASN @GenNextMD HTN, AKI with hematuria, low GFR, Proteinuria >1gm #nephJC? https://t.co/v2meMbGQXO |
| Franklin Loachamin @FranLoachamin RT @Nephro_Sparks: sometimes see patients with relatively fast rising creat. biopsy with few crescents/none (sample error) give steroids in this case #nephjc |
| Bea Concepcion @KidneyBea_n Patients dislike steroids too! RT @NephRodby: I hate the side effects of steroids so I find reasons not to use them for IgA #NephJC |
| Michelle Rheault @rheault_m @NephJC We probably use more steroids in pediatric population. IgA seems to be more acute than the slow progressive dz in adults #NephJC |
| Eleanor Lederer @EleanorLederer #nephjc It is hard just to sit and watch. So what are we doing with our classification systems? |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 If I was that patient, I could not accept that scenario without some intervention #nephJC https://t.co/nEDHGWeXY4 |
 | B. Wagner, M.D. 🇺🇸 @Wagner_Nephro Corticosteroids may be associated with a 55% higher risk for adverse events, https://t.co/Lwsl4kItWS #nephjc |
| Franklin Loachamin @FranLoachamin RT @renalpolitics: #nephjc - favor aggressive supportive care - great BP control, RAASi, eat well, etc. |
| Nephrology Journal Club @NephJC Based on JASN SR, steroids may work, but single centre, not always on RAAS blockade, hence need for RCT #nephjc |
| Roger Rodby @NephRodby @kidney_boy Agree, but for some reason I see benign stable IgA or crescentic in which I hit hard #NephJC |
| TEJAS PATEL MD, FACP, FASN @GenNextMD O come on @hswapnil - you read the JAMA paper already! #nepjJC https://t.co/PPZYBD8Qd4 |
| Nephrology Journal Club @NephJC RT @rheault_m: @NephJC We probably use more steroids in pediatric population. IgA seems to be more acute than the slow progressive dz in adults #NephJC |
| Franklin Loachamin @FranLoachamin RT @edgarvlermamd: IgA Nephropathy from @CJASN #Nephpearls #NephJC 👉🏼 https://t.co/c9g9QUqr5u https://t.co/A1oUocPWkU |
| Gates Colbert, MD @DoctorGates @gratefull080504 Those BMIs! If the US could achieve their BMI levels, half of CKD would be cured. Or more. #NephJC |
| Matthew Sparks, MD @Nephro_Sparks The patients in both TESTING/STOP IgA I would not push steroids on. The crescentic and fast risers were not included in study #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 If you used the prednisone doses in JAMA study in US population, the diabetes would skyrocket , right ? #nephJC |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: IgA Nephropathy treatment algorithm ca. 2017 #ERAEDTA17 🇪🇸 #Nephpearls #NephJC https://t.co/FldbbFgO7S |
| Franklin Loachamin @FranLoachamin RT @NephJC: Background: Background: mostly described in the Lv et al @JASN_News SR https://t.co/FAKfdIrYRe #nephJC Steroids likely work, but data not great https://t.co/W1lQgZDtja |
| Roger Rodby @NephRodby I am very aggressive with RAASi, used dual until study retracted, but did not stop in those on both #NephJC |
| rob @renalpolitics #nephjc -- one major lesson of Stop IgA - aggressive supportive may have better outcomes than steroids, 1/3 pts dropped out of trial with tx |
| Nephrology Journal Club @NephJC @KidneyBea_n @NephRodby exactly. Saw that with our Avocapan chat: https://t.co/uhyu9REWRY #nephjc |
| Nephrology Journal Club @NephJC T1: Let's review methods a. Patient selection GFR 20-120 Proteinuria > 1 g Excl: IgA w/ MCD; Crescentic #NephJC Anything sticks out? https://t.co/hETRmiNI2e |
| Eleanor Lederer @EleanorLederer @Wagner_Nephro #nephjc Steroids. Cant live with them. Cant live without them. |
| Franklin Loachamin @FranLoachamin RT @Nephro_Sparks: agree 👇 #NephJC https://t.co/LtJU9uAyaC |
| Nephrology Journal Club @NephJC @Nephro_Sparks exactly. Pretty good data that immunosuppression works in RPGN like presentation #nephjc |
| TEJAS PATEL MD, FACP, FASN @GenNextMD great point @EleanorLederer #nephJC https://t.co/19jveASib8 |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 It is worth repeating the study population looked very healthy especially BMI compared to US patients #nephJC |
| Nephrology Journal Club @NephJC T1: All pts proteinuria > 1g despite maximal tolerated ACEI/ARB (no dual), no specific duration (unlike STOPiGAN 6 months) #NephJc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @DoctorGates Amen #nephJC |
 | GeriMedJC @GeriMedJC Are you a journal club nerd like us? Check out #NephJC on right now. Steroids and IgA Nephropathy RCT https://t.co/Vocof91kWY |
| Eleanor Lederer @EleanorLederer @Nephro_Sparks #nephjc That is a very important point. |
| Matthew Sparks, MD @Nephro_Sparks RT @EleanorLederer: @Nephro_Sparks #nephjc That is a very important point. |
| Franklin Loachamin @FranLoachamin RT @rheault_m: @NephJC We probably use more steroids in pediatric population. IgA seems to be more acute than the slow progressive dz in adults #NephJC |
| Mohammed Hamdi @mhamdi1986 @EleanorLederer @Wagner_Nephro they are magic but poison at the same time #nephjc |
| Roger Rodby @NephRodby @gratefull080504 The steroid dose not that high, we use that dose all time in MCD, FSGS, SLE etc #NephJC |
| Nephrology Journal Club @NephJC RT @Wagner_Nephro: Corticosteroids may be associated with a 55% higher risk for adverse events, https://t.co/Lwsl4kItWS #nephjc |
| J. Brian Byrd Lab @thebyrdlab #NephJC https://t.co/2ddZroNiCB |
| Franklin Loachamin @FranLoachamin RT @Wagner_Nephro: Corticosteroids may be associated with a 55% higher risk for adverse events, https://t.co/Lwsl4kItWS #nephjc |
| Nephrology Journal Club @NephJC T1: Intervention 0.6-0.8 mg/kg/d oral methylprednisolone (MP) up to max 48 mg for 2 months; tapered off by 8 mg/month in 6-8 months #NephJC |
| TEJAS PATEL MD, FACP, FASN @GenNextMD to broad GFR range....#nephJC https://t.co/GBlmm1rGRt |
| Franklin Loachamin @FranLoachamin RT @edgarvlermamd: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: IgA Nephropathy treatment algorithm ca. 2017 #ERAEDTA17 🇪🇸 #Nephpearls #NephJC https://t.co/FldbbFgO7S |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN Check out the @JAMA_current Editorial on TESTING Trial by @kidneybiz #Nephpearls #NephJC 👉🏼 https://t.co/Sf0VJpaLRI https://t.co/dbqvEW7Foi |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @EleanorLederer : Agreed Sitting and watching is embracing nihilism! #nephJC https://t.co/dWehTtUYog |
| Michelle Rheault @rheault_m @gratefull080504 Not so healthy. ~25% were smokers. Could contribute to the overall infection risk, esp. pulmonary infections. #NephJC |
| Nephrology Journal Club @NephJC @GenNextMD 20 too low? What would you like? #nephjc |
| J. Brian Byrd Lab @thebyrdlab To what extent is the albuminuria of IgA nephropathy due to increased sieving coefficient vs. impaired tubular reabsorption? Known? #NephJC |
| rob @renalpolitics #nephJC - the shorter ACEiARB use is notable (sounding like broken record). what was avg eGFR and BP? |
| Roger Rodby @NephRodby @gratefull080504 Nihilism or do no harm? #NephJC |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @rheault_m: Correct and add that to US population and you still have a less healthy US population #nephJC https://t.co/P16QwLyWom |
| Joel M. Topf, MD FACP @kidney_boy @thebyrdlab this is a glomerular disease would expect it to be sieving coefficient #nephjc |
| Nephrology Journal Club @NephJC Also note, no biopsy/scoring criteria used for inclusion (except excl crescentic/minimal change) #nephjc |
| Nephrology Journal Club @NephJC @renalpolitics indeed. BP pretty good, GFR ~ 60, will come to that #nephjc |
| Franklin Loachamin @FranLoachamin RT @NephRodby: I am very aggressive with RAASi, used dual until study retracted, but did not stop in those on both #NephJC |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @NephRodby : It may not be high to a nephrologist but I think a patient would disagree #nephJC https://t.co/UDcUf6rnHi |
| Nephrology Journal Club @NephJC T1: outcome Composite of ESRD, death from ESRD or 50% decrease in GFR 50% changed to 40% on @nkf report: https://t.co/658PXj26YO #nephJC |
| Roger Rodby @NephRodby Do we really know why a mesangial disease gets proteinuria and especially hematuria? #NephJC |
| Nephrology Journal Club @NephJC @gratefull080504 @NephRodby that is true. and it was high enough to cause bad things...everything is relative? #nephjc |
| J. Brian Byrd Lab @thebyrdlab @kidney_boy There's also tubular atrophy & interstitial fibrosis in some cases, I think? #NephJC |
| Nephrology Journal Club @NephJC @gratefull080504 @EleanorLederer but also important to do the right thing! something may be worse than nothing? #nephjc |
| Nephrology Journal Club @NephJC T1: Sample size based on 30% relative risk reduction (conservative estimate from @JASN_News SR) & ~ 12 % event rate: N was to 750 #NephJc |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN IgA Nephropathy: Emerging tests and therapies ca. 2013 from @CJASN #Nephpearls #NephJC 👉🏼 https://t.co/Y1w2aDtuj4 https://t.co/Kkg7Vz9VAf |
| Michelle Rheault @rheault_m We're getting deep tonight at #NephJC. Don't miss it. https://t.co/vtq8pFb90E |
 | Allin @alinspring RT @edgarvlermamd: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: IgA Nephropathy treatment algorithm ca. 2017 #ERAEDTA17 🇪🇸 #Nephpearls #NephJC https://t.co/FldbbFgO7S |
| Allin @alinspring RT @edgarvlermamd: IgA Nephropathy from @CJASN #Nephpearls #NephJC 👉🏼 https://t.co/c9g9QUqr5u https://t.co/A1oUocPWkU |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @NephJC : This is why PROMs are important #nephJC https://t.co/5nMSs8AGfT |
| Nephrology Journal Club @NephJC RT @gratefull080504: @NephJC : @NephJC : This is why PROMs are important #nephJC https://t.co/5nMSs8AGfT |
| Nephrology Journal Club @NephJC Study funded by Peking University + @nhmrc @CIHR_IRSC @pfizer supplied the drug (no other role) @george_clinical ran the trial #NephJC |
| Nephrology Journal Club @NephJC T1: anything else pique your interest in methods? #nephJc |
| Joel M. Topf, MD FACP @kidney_boy @renalpolitics avg GFR 60, avg BP 123/79 #nephjc |
| TEJAS PATEL MD, FACP, FASN @GenNextMD either go with low GFR (eGFR<45) + Albuminuria >1gm or only albuminuria >1gm with preserved GFR (eGFR>60). 45-60 eGFR grey area #nephJC https://t.co/KFY9V5DDDl |
 | Timothy Yau @Maximal_Change Hi @NephJC Tim yau from @WUNephrology. No COI, lurking tonight. #nephjc |
| Joel M. Topf, MD FACP @kidney_boy hey tim #nephjc |
| Nephrology Journal Club @NephJC @Maximal_Change @NephJC @WUNephrology hey Tim! thanks for saying HI! #nephjc |
 | Lisa ™️ @Lisa30092 @rheault_m @NephJC steroids on kids is a whole lifetime of disrupted gut microbiome which is associated with so many health problems #NephJC |
 | ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @thebyrdlab @kidney_boy Albumin transport in the nephron is more complicated than our simplified model of glomerular/tubular/overflow suggest #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @NephRodby : Fair point but is that a groundswell of interest to find new treatments? I should hope so #nephJC https://t.co/fATA6IOI1c |
| Nephrology Journal Club @NephJC @Lisa30092 @rheault_m @NephJC agreed, but ESRD is probably quite bad on the gut too? #nephjc |
| Nathaniel Reisinger @nephrothaniel RT @ChristosArgyrop: @thebyrdlab @kidney_boy Albumin transport in the nephron is more complicated than our simplified model of glomerular/tubular/overflow suggest #nephjc |
| Nephrology Journal Club @NephJC RT @NephRodby: @gratefull080504 Nihilism or do no harm? #NephJC |
| TEJAS PATEL MD, FACP, FASN @GenNextMD probably former group would require smaller sample size...#nephJC https://t.co/ExhcgFlDdr |
 | varun gaur @TheDrVarun RT @edgarvlermamd: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: IgA Nephropathy treatment algorithm ca. 2017 #ERAEDTA17 🇪🇸 #Nephpearls #NephJC https://t.co/FldbbFgO7S |
| Nephrology Journal Club @NephJC Seems we are oK with methods - lets move on to T2: Results #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 Thank you!! As a kidney transplant recipient 13 years of immunosuppressant treatment has played havoc with my GI system #nephJC https://t.co/l83Z27dD4Z |
| Nephrology Journal Club @NephJC RT @GenNextMD: either go with low GFR (eGFR<45) + Albuminuria >1gm or only albuminuria >1gm with preserved GFR (eGFR>60). 45-60 eGFR grey area #nephJC https://t.co/KFY9V5DDDl |
| Nephrology Journal Club @NephJC T2: Results RCT halted by DSMC (blame @lastwalsh!) Worried about SAEs with steroids #NephJC https://t.co/rQ7C4X9ZZz |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @Lisa30092 @rheault_m @NephJC Thank you for contributing your excellent points ! #nephJC |
| Lisa ™️ @Lisa30092 @NephJC @rheault_m #NephJC probably so, either way something should be done with both diet and probiotics to ensure best outcomes |
| Matthew Sparks, MD @Nephro_Sparks it is important to know answer to this question. in stable IgA with 1g proteinuria. lots of evidence now with STOPIgA and TESTING #nephjc |
| Eleanor Lederer @EleanorLederer #nephjc another question is Is all IgAN the same? What if we could identify inciting factor? |
| Roger Rodby @NephRodby Patients only from China and Australia, I believe that limited ethnicity often a cop out to explain results #NephJC |
| Nephrology Journal Club @NephJC @lastwalsh Only 1/3rd patients enrolled by then, 1.5 years follow up #nephjc |
| Joel M. Topf, MD FACP @kidney_boy I think they should've had a less careful DSMB so we could get some definitive answers for once. #nephjc |
| Timothy Yau @Maximal_Change @kidney_boy Howdy friend #nephjc |
| Nephrology Journal Club @NephJC T2: results Recruited 262/750 planned when trial stopped. Of 523 screened, only 74 seem to have declined? #China #NephJC https://t.co/nckB6NxwV8 |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 For all my #nephJC friends I can tell you that 13 years of transplant meds leads to QOL life challenge that can lead to major health risk |
| Nephrology Journal Club @NephJC @kidney_boy the editorialists say something similar @kidneybiz #nephjc |
| Joel M. Topf, MD FACP @kidney_boy I bet there are a few diseases hiding in the path dx of IgA MT @EleanorLederer: #nephjc another question is "Is all IgAN the same?" |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN IgA Nephropathy: Oxford Pathologic Classification (MEST) #Nephpearls #NephJC 👉🏼 https://t.co/jpOsnnlhLm https://t.co/HMbb8yglJw |
| Lisa ™️ @Lisa30092 @gratefull080504 @rheault_m @NephJC Interested in preventive care, is there anything you attribute to needing transplant? #NephJC |
| Nephrology Journal Club @NephJC RT @gratefull080504: For all my #nephJC friends I can tell you that 13 years of transplant meds leads to QOL life challenge that can lead to major health risk |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @thebyrdlab @kidney_boy There is a very active transepithelial transport mechanism involving the podocyte involving the neonatal FcR & tubular reabsorption #nephjc |
| Nephrology Journal Club @NephJC RT @kidney_boy: I bet there are a few diseases hiding in the path dx of IgA MT @EleanorLederer: I bet there are a few diseases hiding in the path dx of IgA MT @EleanorLederer: #nephjc another question is "Is all IgAN the same?" |
| Nephrology Journal Club @NephJC T2: results Table 1 Young (38 years) 25% smokers BMI 25 ~ 2.5 g proteinuria GFR 60 Almost all Chinese #NephJC https://t.co/48mXuzCxLB |
| Roger Rodby @NephRodby I was very surprised on the infection rate, back to my point, only steroids for 2 months then taper #NephJC |
| TEJAS PATEL MD, FACP, FASN @GenNextMD like a biomarker? circulating factor?? @EleanorLederer #nephJC https://t.co/k48PsCf8R6 |
| J. Brian Byrd Lab @thebyrdlab @ChristosArgyrop @kidney_boy #Megalin #NephJC |
| Matthew Sparks, MD @Nephro_Sparks @gratefull080504 efforts to reduce this burden and my guess after 20 years these will reduce as well. #nephjc |
| Nephrology Journal Club @NephJC RT @NephJC: T2: T2: results Table 1 Young (38 years) 25% smokers BMI 25 ~ 2.5 g proteinuria GFR 60 Almost all Chinese #NephJC https://t.co/48mXuzCxLB |
| B. Wagner, M.D. 🇺🇸 @Wagner_Nephro There were a lot of S1 patients (71,72%)—that could have presented a big challenge for methylprednisolone to overcome. #nephjc |
| Nephrology Journal Club @NephJC RT @ChristosArgyrop: @thebyrdlab @kidney_boy There is a very active transepithelial transport mechanism involving the podocyte involving the neonatal FcR & tubular reabsorption #nephjc |
| Roger Rodby @NephRodby IgA pts should get less infections than nephrotic hypogammaglob, nephrotic patients that get same doses #NephJC |
| Gates Colbert, MD @DoctorGates Why hasn't someone just treated with a slug of galactose to those galactose deficient IgA? (sarcasm) :) #palliativesugar #nephjc |
| Nephrology Journal Club @NephJC RT @Wagner_Nephro: There were a lot of S1 patients (71,72%)—that could have presented a big challenge for methylprednisolone to overcome. #nephjc |
| Matthew Sparks, MD @Nephro_Sparks @GenNextMD @EleanorLederer this is sort of the the hope with PLA2R in Membranous. not there yet but maybe... needed for other GN dz #nephjc |
| Mina @mina52926039 Lifelong disease.. with short term follow-up, hard to say that they won’t all progress regardless to steroids or deceased proteinuri #nephjc |
| Eleanor Lederer @EleanorLederer @edgarvlermamd @CJASN #nephjc Thanks, Edgar. But we have to ask "do different pathologies really mean a different process?" |
| Nephrology Journal Club @NephJC From Table 1: as Kevin has pointed out, young, GFR 60 and BMI 25. Almost all Chinese (very few Australain) #nephjc |
| Joel M. Topf, MD FACP @kidney_boy RT @Mina52926039: Lifelong disease.. with short term follow-up, hard to say that they won’t all progress regardless to steroids or deceased proteinuri #nephjc |
| Timothy Yau @Maximal_Change @NephJC Never noticed in this study that about half had crescents although they excluded rpgn #nephjc |
| Roger Rodby @NephRodby Other IgA studies did not have this kind of infection rate correct? Something unlucky me thinks #NephJC |
| B. Wagner, M.D. 🇺🇸 @Wagner_Nephro (And a lot of T1, T2... hard to get a good effect size when you are tackling such aggressive disease to start.) #nephjc |
| Nephrology Journal Club @NephJC @Maximal_Change Indeed, only excluded if crescents > 50% #NephJC |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 This underscores the absence of risk-benefit conversation #Dialysis has lots of risks It is accepted without discussion #nephJC https://t.co/fZoWo7qUBo |
| TEJAS PATEL MD, FACP, FASN @GenNextMD quite thin population, GFR preserved relatively #nephJC https://t.co/AEeg888N22 |
| Nephrology Journal Club @NephJC T2: let's see efficacy before adverse events Steroids significantly better despite 1/3rd N, short FU! 8 vs 20 GFR slope way better #NephJC https://t.co/25qtrOjMRM |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN The many faces of IgA Nephropathy from @ph_nachman @UNC #Nephpearls #NephJC 👉🏼 https://t.co/312tqBD71u https://t.co/d9Vje2nC5I |
| Nephrology Journal Club @NephJC T2: let's see efficacy before adverse events Steroids significantly better despite 1/3rd N, short FU! 8 vs 20 GFR slope way better #NephJC |
| Matthew Sparks, MD @Nephro_Sparks @Mina52926039 I think the point is that it would delay progression. #nephjc |
| Nephrology Journal Club @NephJC T2: look at GFR in particular. Early rise in GFR with steroids? Can anyone explain that? #NephJC https://t.co/QN0OwTnoHo |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 Are there any IGa patients on this #nephJC chat ? Please speak up |
| Joel M. Topf, MD FACP @kidney_boy or would it? RT @Nephro_Sparks: @Mina52926039 I think the point is that it would delay progression. #nephjc |
| Michelle Rheault @rheault_m RT @NephJC: T2: T2: let's see efficacy before adverse events Steroids significantly better despite 1/3rd N, short FU! 8 vs 20 GFR slope way better #NephJC |
| Roger Rodby @NephRodby Mean U protein 2.5 g/day, StopIgA was 1 gram. This is a big difference. TESTING better population to study #NephJC |
| Timothy Yau @Maximal_Change For those of you worried about longer term steroids in IgAN would you use the following? #NephJC |
| Nephrology Journal Club @NephJC RT @NephRodby: Mean U protein 2.5 g/day, StopIgA was 1 gram. This is a big difference. TESTING better population to study #NephJC |
| Michelle Rheault @rheault_m RT @NephRodby: Mean U protein 2.5 g/day, StopIgA was 1 gram. This is a big difference. TESTING better population to study #NephJC |
| Joel M. Topf, MD FACP @kidney_boy RT @gratefull080504: Are there any IGa patients on this #nephJC chat ? Please speak up |
| Nephrology Journal Club @NephJC thats a twitter poll RT @Maximal_Change: For those of you worried about longer term steroids in IgAN would you use the following? #NephJC |
| Nephrology Journal Club @NephJC RT @gratefull080504: Are there any IGa patients on this #nephJC chat ? Please speak up |
| Nephrology Journal Club @NephJC T2: they looked at urinary creatinine (efigure 3) Seems to be lower with steroids - ? Sarcopenia #NephJc https://t.co/cXkr7chRgc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 Tonight's discussion underscores importance of developing the #patientvoice in #kidneydisease Group think needs to be challenged #nephJC |
| Matthew Sparks, MD @Nephro_Sparks RT @NephRodby: Mean U protein 2.5 g/day, StopIgA was 1 gram. This is a big difference. TESTING better population to study #NephJC |
| Roger Rodby @NephRodby The prob with 90% of all IgA studies is that you are not studying the pts at risk of progression #NephJC |
| Nephrology Journal Club @NephJC BP not much different in both groups #NephJC eFigure 1 https://t.co/5d9lLoABnh |
| Nephrology Journal Club @NephJC And some subgroups on primary outcome No signal here? #NephJC https://t.co/FPbY2qL26B |
| Nephrology Journal Club @NephJC @NephRodby coming up SAEs next for you Roger! #nephjc |
| Nephrology Journal Club @NephJC RT @GenNextMD: quite thin population, GFR preserved relatively #nephJC https://t.co/AEeg888N22 |
| Timothy Yau @Maximal_Change RT @NephRodby: The prob with 90% of all IgA studies is that you are not studying the pts at risk of progression #NephJC |
| TEJAS PATEL MD, FACP, FASN @GenNextMD may be volume expansion and dilutional? #nephJC https://t.co/Z8As5sylru |
| Nephrology Journal Club @NephJC @NephRodby Which patients would you choose? Proteinuria + add biopsy criteria? #nephjc |
 | Alex Meraz @NephroGuy RT @Nephro_Sparks: it is important to know answer to this question. in stable IgA with 1g proteinuria. lots of evidence now with STOPIgA and TESTING #nephjc |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @thebyrdlab @kidney_boy #Megalin may be a minor player. See section on FcNR https://t.co/7Ehj9MGIU7 https://t.co/Vp25AQfcgg https://t.co/7XeksUMzeQ #NephJC |
| Nephrology Journal Club @NephJC T2: on to SAEs 28 vs 4, mostly driven by infections, incl 2 deaths #NephJC https://t.co/GNZGR0qM9H |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 How many #nephJC members have patients with this type of #bloodpressure ? https://t.co/pzajNqQUfh |
| TEJAS PATEL MD, FACP, FASN @GenNextMD agreed....@gratefull080504 #nephJC https://t.co/ba22hzPI2D |
| Nephrology Journal Club @NephJC T2 subgroup analysis for SAEs Again no signal here? #NephJC https://t.co/Vj3PgUu1ET |
| DrJacquescoleyMusic @jacquescoley RT @NephJC: T2 subgroup analysis for SAEs Again no signal here? #NephJC https://t.co/Vj3PgUu1ET | |
| Timothy Yau @Maximal_Change @NephRodby The recent @AJKDonline paper that @TWhittier_RUSH wrote on looked at MMF in crescent of IgAN. Only one I can think of #nephjc |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN Role of COMPLEMENT in the parhogenesis of IgA Nephropathy from @JASN_News #Nephpearls #NephJC 👉🏼 https://t.co/r5kwTQm0Yd https://t.co/rQ5KQB2giH |
| Roger Rodby @NephRodby 262 pts of planned 650 enrolled and primary outcome still p 0.02! There is something here #NephJC |
| Matthew Sparks, MD @Nephro_Sparks Kevin on point as always #NephJC https://t.co/umPOBNT0K3 |
| Nephrology Journal Club @NephJC @gratefull080504 with IgA, GFR 60, not unusual to achieve good BP with BP medicines #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 Why is this ? #nephJC https://t.co/tbH8rQXbvK |
| Eleanor Lederer @EleanorLederer #nephjc We are trapped by our language. We call it IgAN. But this is a pathologic "immunofluorescence" diagnosis. |
| Nephrology Journal Club @NephJC yes, event rate higher than expected1 MT @NephRodby: 262/650 enrolled and primary outcome still p 0.02! There is something here #NephJC |
 | Nefrología HGM @nefrologiaHGM RT @edgarvlermamd: @CJASN IgA Nephropathy: @CJASN IgA Nephropathy: Emerging tests and therapies ca. 2013 from @CJASN #Nephpearls #NephJC 👉🏼 https://t.co/Y1w2aDtuj4 https://t.co/Kkg7Vz9VAf |
| Nephrology Journal Club @NephJC RT @EleanorLederer: #nephjc We are trapped by our language. We call it IgAN. But this is a pathologic "immunofluorescence" diagnosis. |
| Nefrología HGM @nefrologiaHGM RT @edgarvlermamd: IgA Nephropathy from @CJASN #Nephpearls #NephJC 👉🏼 https://t.co/c9g9QUqr5u https://t.co/A1oUocPWkU |
| Nephrology Journal Club @NephJC T2: @NephRodby also note that slope of GFR (-7ml/min/per year) way higher than in STOPigA (-1.65) #NephJC |
| Roger Rodby @NephRodby @NephJC biopsy plays major part in my decision #NephJC |
| Nefrología HGM @nefrologiaHGM RT @edgarvlermamd: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: IgA Nephropathy treatment algorithm ca. 2017 #ERAEDTA17 🇪🇸 #Nephpearls #NephJC https://t.co/FldbbFgO7S |
| Nefrología HGM @nefrologiaHGM Retweeted Edgar V. Lerma 🇵🇭 (@edgarvlermamd): IgA Nephropathy from @CJASN #Nephpearls #NephJC 👉🏼... https://t.co/hvjJmJq5Wl |
| Nefrología HGM @nefrologiaHGM Retweeted Edgar V. Lerma 🇵🇭 (@edgarvlermamd): @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: IgA Nephropathy... https://t.co/8EcnNPq2La |
| Timothy Yau @Maximal_Change @NephJC Small n but 7x adverse events is a big deal. Dialysis also a big deal. Just pointing out the obvious #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 What is in the R+D pipeline for IGaN? #nephJC |
| Nephrology Journal Club @NephJC RT @Maximal_Change: @NephJC Small n but 7x adverse events is a big deal. Dialysis also a big deal. Just pointing out the obvious #nephjc |
| Franklin Loachamin @FranLoachamin RT @NephJC: T1: T1: Intervention 0.6-0.8 mg/kg/d oral methylprednisolone (MP) up to max 48 mg for 2 months; tapered off by 8 mg/month in 6-8 months #NephJC |
| Matthew Sparks, MD @Nephro_Sparks team. I have to run. great chat and thanks to Swap for leading the discussion and Amit for the writeup. #nephjc |
| Nefrología HGM @nefrologiaHGM RT @kidney_boy: For #NephJC here is the #VisualAbstract for STOP-IgA https://t.co/PQPVKx8H84 |
| Nefrología HGM @nefrologiaHGM Retweeted Joel Topf, MD FACP (@kidney_boy): For #NephJC here is the #VisualAbstract for STOP-IgA... https://t.co/KLaYHKhqVV |
| Roger Rodby @NephRodby If adverse events had not occurred, study could have been stopped early for + results! Think about that #NephJC |
| TEJAS PATEL MD, FACP, FASN @GenNextMD likely population too sensitive to steroid..effect and side effect? also they chg reduction in GFR from 50% to 40% as an end point...#nephJC https://t.co/Q05dduQCld |
| Timothy Yau @Maximal_Change @Nephro_Sparks See ya matt #nephjc |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @thebyrdlab @kidney_boy You are making me break radio silence on a #NephJC I didn't want to participate #BallardieRoberts4IgA https://t.co/Uh2mfJblQd Signing off :) |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @Nephro_Sparks See you @Nephro_Sparks I am leaving soon too #nephJC |
| Timothy Yau @Maximal_Change RT @NephRodby: If adverse events had not occurred, study could have been stopped early for + results! Think about that #NephJC |
| Nephrology Journal Club @NephJC @gratefull080504 lots. Budesonide (see NEFIGAN RCT), Blisibimod (https://t.co/p1OD1ZaeXx) etc #nephjc |
| J. Brian Byrd Lab @thebyrdlab @ChristosArgyrop @kidney_boy thanks, @ChristosArgyrop! #nephjc |
| Nephrology Journal Club @NephJC @NephRodby likely not - stopping rules for efficacy are more stringent...#partpooper #nephjc |
| Roger Rodby @NephRodby Ironically, this study will move me to finally use steroids for proteinuria IgA , not just histology #NephJC |
| Franklin Loachamin @FranLoachamin RT @NephJC: T1: T1: outcome Composite of ESRD, death from ESRD or 50% decrease in GFR 50% changed to 40% on @nkf report: https://t.co/658PXj26YO #nephJC |
| Joel M. Topf, MD FACP @kidney_boy RT @NephRodby: If adverse events had not occurred, study could have been stopped early for + results! Think about that #NephJC |
| Nephrology Journal Club @NephJC T3: so what now? - SAEs not surprising at all, right? Seen in other steroid trials, STOPIgA eg from @JASN_News SR same group #nephJC https://t.co/3QY2E6pLwv |
| Timothy Yau @Maximal_Change @NephRodby 2 months then taper? Proteinuria gets better but then bounces up again. Would you rechallenge or use steroid sparing agent? #nephjc |
| Roger Rodby @NephRodby @NephJC You are right but studies do get stopped early if results too positive, unethical to deprive #NephJC |
| Nephrology Journal Club @NephJC Anything else you want to see from Results? Lets move on to T3: what happens next #nephjc |
| Nephrology Journal Club @NephJC T3: what's your take home? Does this add anything? Will this change your practice? #NephJC |
| Joel M. Topf, MD FACP @kidney_boy Was 2015 a bad year for swine flu? Could this be an influenza epidemic issue. Not a good time to use 'roids. #nephjc |
| Nephrology Journal Club @NephJC @NephRodby hmm you are not perplexed by GFR rise with steroids?? maybe benefit too good? #nephjc |
| Gates Colbert, MD @DoctorGates @NephRodby Do you see value in Pred 20 mg? (i.e. 0.3 mg/kg) The skim milk version. #Nephjc |
| Franklin Loachamin @FranLoachamin RT @EleanorLederer: #nephjc We are trapped by our language. We call it IgAN. But this is a pathologic "immunofluorescence" diagnosis. |
| Nephrology Journal Club @NephJC Good Q RT @kidney_boy: Was 2015 a bad year for swine flu? Could this be an influenza epidemic issue. Not a good time to use 'roids. #nephjc |
| Roger Rodby @NephRodby @Maximal_Change 2 months was protocol, but see Figure 3, must be some memory effect #NephJC |
| Nephrology Journal Club @NephJC @ChristosArgyrop @thebyrdlab @kidney_boy heh! You are a steroid believer in this setting, yes? #nephjc |
| TEJAS PATEL MD, FACP, FASN @GenNextMD #flushot - double dose...@kidney_boy #nephJC https://t.co/LtJ9yFUfXj |
| Timothy Yau @Maximal_Change @DoctorGates @NephRodby The AIN version of IgAN. #nephjc |
| Roger Rodby @NephRodby @DoctorGates 2o mg pred, I don't know I think it is s__t or get off the pot #NephJC |
| Eleanor Lederer @EleanorLederer @NephRodby #nephjc For all of my questioning, this was a well done study. I am still on the fence about steroids. And thanks for the great summary. |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 My final thoughts as I leave: Were the IGaN patient advocacy groups present at #nephJC tonight? If not missed opp. I did invite them |
| Nephrology Journal Club @NephJC RT @EleanorLederer: @NephRodby #nephjc For all of my questioning, this was a well done study. I am still on the fence about steroids. And thanks for the great summary. |
| rob @renalpolitics #nephjc id still want to be pushed into immunosppression for rarer rpgn presentations and hold off on most patients...if it was me though... |
| Matthew Sparks, MD @Nephro_Sparks RT @gratefull080504: My final thoughts as I leave: My final thoughts as I leave: Were the IGaN patient advocacy groups present at #nephJC tonight? If not missed opp. I did invite them |
| Nephrology Journal Club @NephJC The GFR decline was very fast 7ml/min/year....way faster. Chinese patients, more proteinuria, less duration RAAS, or chance? #nephjc |
| Roger Rodby @NephRodby @NephJC GFR rise with steroids? hemodynamic, not surprised, don't think a few months is bad #NephJC |
| Franklin Loachamin @FranLoachamin RT @kidney_boy: Was 2015 a bad year for swine flu? Could this be an influenza epidemic issue. Not a good time to use 'roids. #nephjc |
| Nephrology Journal Club @NephJC @NephRodby @NephJC if this drove results, wouldnt you want to see ESKD benefit to be sure? #nephjc |
| Roger Rodby @NephRodby @NephJC I may be on fence too but leaning a lot more after this paper! #NephJC |
| Timothy Yau @Maximal_Change Does anyone know if there are onoing IgAN studies in progress that may give us answers? #NephJC |
| Nephrology Journal Club @NephJC T3: now TESTING moving on to a lower dose RCT (0.4-0.6 mg/kg/day up to 32mg) https://t.co/IqMxhx0nn7? #NephJC |
| Eleanor Lederer @EleanorLederer @NephRodby Could this be an effect on AA metabolism? #nephjc |
| Nephrology Journal Club @NephJC @EleanorLederer @NephRodby they speculate maybe sarcopenia (urine creatinine decreased in steroid group FWIW) #nephjc |
 | george miguelito @georgemiguelito RT @edgarvlermamd: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: @CJASN MT @Marici18 @EvaRodriguezGa6 FLOEGE: IgA Nephropathy treatment algorithm ca. 2017 #ERAEDTA17 🇪🇸 #Nephpearls #NephJC https://t.co/FldbbFgO7S |
| Franklin Loachamin @FranLoachamin RT @NephJC: The GFR decline was very fast 7ml/min/year....way faster. Chinese patients, more proteinuria, less duration RAAS, or chance? #nephjc |
| Joel M. Topf, MD FACP @kidney_boy If you had a woman 25 with IgAN and 1.5 grams of protein, nl GFR. Wants to get pregnant, would that push you to treat b4 pregnancy? #nephjc |
| Franklin Loachamin @FranLoachamin RT @renalpolitics: #nephjc id still want to be pushed into immunosppression for rarer rpgn presentations and hold off on most patients...if it was me though... |
| Timothy Yau @Maximal_Change @NephJC @NephRodby Yes. But can't do 10 year studies anymore. :( #nephjc |
| Michelle Rheault @rheault_m RT @NephJC: T3: T3: now TESTING moving on to a lower dose RCT (0.4-0.6 mg/kg/day up to 32mg) https://t.co/IqMxhx0nn7? #NephJC |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN MT @CharlieTomson @drjamesburton FELLSTROM: NEFIGAN Targeted-release budesonide in IgA nephropathy #ERAEDTA17 🇪🇸 #Nephpearls #NephJC https://t.co/tqOajVUqb8 |
| Roger Rodby @NephRodby GFR loss may be high, but these are more proteinuric pts than usual, and that is despite RAASi, Progression = study #NephJC |
| Nephrology Journal Club @NephJC @tulunsokit @NephJC thats the claim....not sure enough data to support #nephjc |
| Timothy Yau @Maximal_Change RT @NephJC: T3: T3: now TESTING moving on to a lower dose RCT (0.4-0.6 mg/kg/day up to 32mg) https://t.co/IqMxhx0nn7? #NephJC |
| Nephrology Journal Club @NephJC RT @kidney_boy: If you had a woman 25 with IgAN and 1.5 grams of protein, nl GFR. Wants to get pregnant, would that push you to treat b4 pregnancy? #nephjc |
| Joel M. Topf, MD FACP @kidney_boy @tulunsokit @NephJC could they be more susceptible to steroids? Other side f the same coin #nephjc |
| TEJAS PATEL MD, FACP, FASN @GenNextMD https://t.co/QICF6x8WPC @Maximal_Change #nephJC https://t.co/6kuXQqoC0s |
| Nephrology Journal Club @NephJC @Maximal_Change the low dose TESTING is one (0.4-0.6 mg/kg/d) and other non-steroid RCTs I am sure #nephjc |
| Kevin J. Fowler Principal The Voice of the Patient @gratefull080504 @EleanorLederer Thank you @EleanorLederer I learn a lot from #nephJC |
| Roger Rodby @NephRodby @kidney_boy man that is tough call, pregnancy, treat first, prob not #NephJC |
| Timothy Yau @Maximal_Change @ChristosArgyrop @NephRodby How much CyC? Low dose po? #nephjc |
| Roger Rodby @NephRodby TESTING now lower dose, watch them lose the effect, no SAEs, no effect. #NephJC |
| Nephrology Journal Club @NephJC @tulunsokit @NephJC this study says Asians do worse: https://t.co/5WF0wSF03K (KI, gated) #nephjc |
| Roger Rodby @NephRodby There is no free lunch in treating any GN #NephJC |
| Nephrology Journal Club @NephJC Bold Prediction! @NephRodby: TESTING now lower dose, watch them lose the effect, no SAEs, no effect. #NephJC |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @NephJC @thebyrdlab @kidney_boy Not at these mega doses, not as monotherapy and in patients with aggressive clinical disease (eGFR decline/incr in proteinuria etc) #NephJC |
| TEJAS PATEL MD, FACP, FASN @GenNextMD Good night and Thank you everyone. I enjoyed the discussion #nephjc |
| Nephrology Journal Club @NephJC QFT, sad but probably true @NephRodby: There is no free lunch in treating any GN #NephJC |
| Nephrology Journal Club @NephJC @GenNextMD g'night, thanks for coming Tejas #nephjc |
| Eleanor Lederer @EleanorLederer @kidney_boy #nephjc No. I would encourage her to get pregnant while she can. |
| Nephrology Journal Club @NephJC RT @NephRodby: GFR loss may be high, but these are more proteinuric pts than usual, and that is despite RAASi, Progression = study #NephJC |
| Timothy Yau @Maximal_Change Lots on the horizon still #nephjc #nephforward https://t.co/fYf5W4Ypjt |
| Roger Rodby @NephRodby So if Asians do worse, those are the ones you WANT to study. IgA trials fraught with low risk patients #NephJC |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @Maximal_Change @NephRodby Pred 40 mg/d (reduced to 10 mg/d by 2 yr) & CyC1.5 mg/kg (adjusted down to the nearest 50 mg) x 3 mo, then azathioprine x 2 yr #NephJC |
| Nephrology Journal Club @NephJC @NephJC @tulunsokit though @geddescc did not find much true geographical variation https://t.co/hj0vSEAzyv (no Asians though) #nephjc |
| Joel M. Topf, MD FACP @kidney_boy I'm gonna use ACTH, 'ause no side effects! (At least that's what the Italians found) #nephjc |
| Nephrology Journal Club @NephJC Agreed RT @EleanorLederer: @kidney_boy #nephjc No. I would encourage her to get pregnant while she can. |
| Timothy Yau @Maximal_Change @ChristosArgyrop @NephRodby Excellent, thx for the detailed protocol. #nephjc |
| Nephrology Journal Club @NephJC ACTHAR FTW. Not! RT @kidney_boy: I'm gonna use ACTH, 'ause no side effects! (At least that's what the Italians found) #nephjc |
| Franklin Loachamin @FranLoachamin RT @NephRodby: So if Asians do worse, those are the ones you WANT to study. IgA trials fraught with low risk patients #NephJC |
| Michelle Rheault @rheault_m @NephRodby CureGN longitudinal cohort study (https://t.co/S7EFWNJVcA) may help to identify IgA pts at high risk of progression. #NephJC |
| Roger Rodby @NephRodby DSMC had to stop it but I bet they're not happy given preliminary results #NephJC |
| Franklin Loachamin @FranLoachamin RT @kidney_boy: I'm gonna use ACTH, 'ause no side effects! (At least that's what the Italians found) #nephjc |
| Nephrology Journal Club @NephJC RT @ChristosArgyrop: @thebyrdlab @kidney_boy You are making me break radio silence on a #NephJC I didn't want to participate #BallardieRoberts4IgA https://t.co/Uh2mfJblQd Signing off :) |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @Maximal_Change @NephRodby Ie the #BallardieRoberts. Downplayed in GL because of the inconsistent use of ACEi, but note pts had rapidly deteriorating renal fx #NephJC |
| Nephrology Journal Club @NephJC RT @rheault_m: @NephRodby CureGN longitudinal cohort study (https://t.co/S7EFWNJVcA) may help to identify IgA pts at high risk of progression. #NephJC |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN MT @renalpages What's up and coming for treatment of IgA Nephropathy 2016 #ERAEDTA16 #Nephpearls #NephJC https://t.co/6GN8xQVnB2 |
| Gates Colbert, MD @DoctorGates @NephRodby - Great discussion on steroids NOW @ASN https://t.co/UNxRPgzHR9 #nephjc |
| Michelle Rheault @rheault_m @kidney_boy The only side effect of ACTH is the crushing of your soul as you prescribe it. #NephJC |
| Franklin Loachamin @FranLoachamin RT @rheault_m: @NephRodby CureGN longitudinal cohort study (https://t.co/S7EFWNJVcA) may help to identify IgA pts at high risk of progression. #NephJC |
| Roger Rodby @NephRodby @kidney_boy I'm gonna use ACTH when it costs less that the GNP of Liechtenstein #NephJC |
| Nephrology Journal Club @NephJC Are you happy @lastwalsh? RT @NephRodby: DSMC had to stop it but I bet they're not happy given preliminary results #NephJC |
| Eleanor Lederer @EleanorLederer #nephjc Thanks so much, guys. Great discussion. |
| Franklin Loachamin @FranLoachamin RT @edgarvlermamd: @CJASN MT @renalpages What's up and coming for treatment of IgA Nephropathy 2016 #ERAEDTA16 #Nephpearls #NephJC https://t.co/6GN8xQVnB2 |
| Timothy Yau @Maximal_Change RT @rheault_m: @kidney_boy The only side effect of ACTH is the crushing of your soul as you prescribe it. #NephJC |
| Joel M. Topf, MD FACP @kidney_boy RT @rheault_m: @kidney_boy The only side effect of ACTH is the crushing of your soul as you prescribe it. #NephJC |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @Maximal_Change @NephRodby Primary reference for the protocol https://t.co/eL182Jtt8H Pay attention to the criteria for entry (impaired, declining renal fx #NephJC |
| Swapnil Hiremath @hswapnil@bsky.social @hswapnil @kidney_boy Could Chinese patients be like Italians too? 🤔#NephJC |
| Matthew Sparks, MD @Nephro_Sparks RT @ChristosArgyrop: @Maximal_Change @NephRodby Primary reference for the protocol https://t.co/eL182Jtt8H Pay attention to the criteria for entry (impaired, declining renal fx #NephJC |
| Nephrology Journal Club @NephJC @ChristosArgyrop @Maximal_Change @NephRodby Those patients would get excluded from current IgA Trials, though? #NephJC |
| rob @renalpolitics #nephjc unfortunate contrast bw this trial and @hswapnil RT re new secondary prev cards trials. Underfunded Kidneys :( |
| Roger Rodby @NephRodby IgA is just too heterogeneous a GN to study. may be the most heterogeneous. #NephJC |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN Eculizumab for treatment of crescentic IgA Nephropathy #Nephpearls #NephJC 👉🏼 https://t.co/3BaXDlG961 https://t.co/4mzEmeB7LM |
| Nephrology Journal Club @NephJC thanks everyone! great discussion. Any final questions/thoughts? #nephjc |
| Nephrology Journal Club @NephJC RT @renalpolitics: #nephjc unfortunate contrast bw this trial and @hswapnil RT re new secondary prev cards trials. Underfunded Kidneys :( |
| Nephrology Journal Club @NephJC RT @NephRodby: IgA is just too heterogeneous a GN to study. may be the most heterogeneous. #NephJC |
| Franklin Loachamin @FranLoachamin RT @edgarvlermamd: @CJASN Eculizumab for treatment of crescentic IgA Nephropathy #Nephpearls #NephJC 👉🏼 https://t.co/3BaXDlG961 https://t.co/4mzEmeB7LM |
| Nephrology Journal Club @NephJC Check out our once a week newsletter (curated by Joel/Swapnil + new @DoctorGates !) https://t.co/5aumn8ImwF #NephJC |
 | Arvind Canchi (Conjeevaram)🇮🇳 @arvindcanchi @NephRodby #Nephjc Some data #IgA in India. https://t.co/lq5O8Ct7w6 |
| Franklin Loachamin @FranLoachamin #nephjc thanks everyone. Good discussion |
| Roger Rodby @NephRodby So sad rituximab does not seem to work for IgA :( #NephJC |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN FALK's Treatment of IgA Nephropathy ca. 2014 #Nephpearls #NephJC https://t.co/fLBzSzEs2S |
| Nephrology Journal Club @NephJC #Troll RT @NephRodby: So sad rituximab does not seem to work for IgA :( #NephJC |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @NephJC @Maximal_Change @NephRodby Correct - but these are the patients who progress. Tthe present study also included many pts w impaired renal fx, or rapid decline #NephJC |
| Roger Rodby @NephRodby Thanks for hosting Swap, nice job. Didn't diss RAASi once! "Keep hope alive" #NephJC |
| Joel M. Topf, MD FACP @kidney_boy #NephJC live with fellows, residents, and med students https://t.co/CMWYBNGAgB |
| Nephrology Journal Club @NephJC This is @hswapnil signing off. If you are hungry for more, come back at 8 pm BST tomorrow #nephjc |
| Nephrology Journal Club @NephJC Nicely done! hope you all come back! RT @kidney_boy: #NephJC live with fellows, residents, and med students https://t.co/SWZmYBrvOS |
| Roger Rodby @NephRodby RT @kidney_boy: #NephJC live with fellows, residents, and med students https://t.co/CMWYBNGAgB |
| Arvind Canchi (Conjeevaram)🇮🇳 @arvindcanchi @NephRodby #nephjc https://t.co/z1FwllHheX |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @NephJC @Maximal_Change @NephRodby This is also my problem with the recent IgA studies. The Risk-Benefit ratio of immunosuppression is unfavorable for most pts #NephJC |
| B. Wagner, M.D. 🇺🇸 @Wagner_Nephro RT @rheault_m: @kidney_boy The only side effect of ACTH is the crushing of your soul as you prescribe it. #NephJC |
| Roger Rodby @NephRodby @kidney_boy 7 people and only one Stella open? #NephJC |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @NephRodby The many faces of IgA Nephropathy from @ph_nachman @UNC #Nephpearls #NephJC https://t.co/boYNR0l9gL |
| Joel M. Topf, MD FACP @kidney_boy Great chat. #nephjc |
| Michelle Rheault @rheault_m @NephRodby CureGN IgA cohort is relatively low risk. (Guess who's on their patient newsletter committee?) #NephJC https://t.co/xpufm6NmE6 https://t.co/O0TxEjpYBR |
| Nephrology Journal Club @NephJC RT @rheault_m: @NephRodby CureGN IgA cohort is relatively low risk. (Guess who's on their patient newsletter committee?) #NephJC https://t.co/xpufm6NmE6 https://t.co/O0TxEjpYBR |
| ChristosArgyropoulos MD, PhD PharmanukerInChief @ChristosArgyrop @NephJC @Maximal_Change @NephRodby but if you use clinical criteria to select the rapid progressors (similar to what we do for membranous) then we should go for it #NephJC |
| Lisa ™️ @Lisa30092 @edgarvlermamd @CJASN Very interesting. In light of Asian pre-disposition note their normal diet is lots & lots & lots of FISH #NephJC |
| Mohammed Hamdi @mhamdi1986 Thank u everyone for the great discussion #nephjc |
| Swapnil Hiremath @hswapnil@bsky.social @hswapnil RT @rheault_m: @kidney_boy The only side effect of ACTH is the crushing of your soul as you prescribe it. #NephJC |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN IgA Nephropathy: Risk Factors for Progression #Nephpearls #NephJC https://t.co/wwuiVDphpo |
| B. Wagner, M.D. 🇺🇸 @Wagner_Nephro Great discussion. Very witty, @rhealult_m. Interesting take, @NephRodby. #nephjc |
| B. Wagner, M.D. 🇺🇸 @Wagner_Nephro Thanks, @NephJC, @kidney_boy, @hswapnil, @EleanorLederer, et al #nephjc |
| Lisa ™️ @Lisa30092 It seems like people would get less diseases if people weren't ashamed to be race-realists because race & genes do discriminate... #NephJC |
| Edgar V. Lerma 🇵🇭 @edgarvlermamd @CJASN Rituximab failed to ⬇️ levels of specific antibodies w/ pathogenetic roles in IgA nephropathy #Nephpearls #NephJC 👉🏼 https://t.co/58ZAerhPMF https://t.co/P2Jb2YCUFH |
 | Matt Sampson @kidneyomicsamps RT @rheault_m: @NephRodby CureGN longitudinal cohort study (https://t.co/S7EFWNJVcA) may help to identify IgA pts at high risk of progression. #NephJC |
 | Mo Alzubaidi @NephrosisMo RT @NephRodby: There is no free lunch in treating any GN #NephJC |
 | S Francisco de Quito @SFQuito RT @FranLoachamin: #NephJC hey guys good night . Franklin Loachamin. Quito Ecuador. Ped neph. NO COI |
| Franklin Loachamin @FranLoachamin RT @ChristosArgyrop: @NephJC @Maximal_Change @NephRodby This is also my problem with the recent IgA studies. The Risk-Benefit ratio of immunosuppression is unfavorable for most pts #NephJC |
| Franklin Loachamin @FranLoachamin Maybe a dehydration https://t.co/eujaAlEuRA |
| Franklin Loachamin @FranLoachamin RT @edgarvlermamd: @NephRodby The many faces of IgA Nephropathy from @ph_nachman @UNC #Nephpearls #NephJC https://t.co/boYNR0l9gL |
| Franklin Loachamin @FranLoachamin RT @rheault_m: @NephRodby CureGN IgA cohort is relatively low risk. (Guess who's on their patient newsletter committee?) #NephJC https://t.co/xpufm6NmE6 https://t.co/O0TxEjpYBR |
| Franklin Loachamin @FranLoachamin RT @edgarvlermamd: @CJASN IgA Nephropathy: @CJASN IgA Nephropathy: Risk Factors for Progression #Nephpearls #NephJC https://t.co/wwuiVDphpo |
| Franklin Loachamin @FranLoachamin RT @Lisa30092: It seems like people would get less diseases if people weren't ashamed to be race-realists because race & genes do discriminate... #NephJC |
 | محذوف @milardport RT @NephJC: Agreed RT @EleanorLederer: Agreed RT @EleanorLederer: @kidney_boy #nephjc No. I would encourage her to get pregnant while she can. |
| محذوف @milardport RT @NephJC: T1: Sample size based on 30% relative risk reduction (conservative estimate from @JASN_News SR) & ~ 12 % event rate: N was to 750 #NephJc |
| محذوف @milardport RT @NephJC: T2: T2: Results RCT halted by DSMC (blame @lastwalsh!) Worried about SAEs with steroids #NephJC https://t.co/rQ7C4X9ZZz |
| محذوف @milardport RT @NephJC: And an excellent summary for #NephJC from @LangoteAmit https://t.co/oHuORfmKhO |
| محذوف @milardport RT @NephJC: #Troll RT @NephRodby: #Troll RT @NephRodby: So sad rituximab does not seem to work for IgA :( #NephJC |
| محذوف @milardport RT @NephJC: Based on JASN SR, steroids may work, but single centre, not always on RAAS blockade, hence need for RCT #nephjc |
| محذوف @milardport RT @NephJC: @tulunsokit @NephJC this study says Asians do worse: @tulunsokit @NephJC this study says Asians do worse: https://t.co/5WF0wSF03K (KI, gated) #nephjc |
| محذوف @milardport RT @NephJC: T3: T3: so what now? - SAEs not surprising at all, right? Seen in other steroid trials, STOPIgA eg from @JASN_News SR same group #nephJC https://t.co/3QY2E6pLwv |
| محذوف @milardport RT @NephJC: We will be discussing the @JAMA_current RCT TESTING (Therapeutic Evaluation of Steroids in IgA Nephropathy Global) #NephJC |
| محذوف @milardport RT @NephJC: And some subgroups on primary outcome No signal here? #NephJC https://t.co/FPbY2qL26B |
| محذوف @milardport RT @NephJC: T2: T2: look at GFR in particular. Early rise in GFR with steroids? Can anyone explain that? #NephJC https://t.co/QN0OwTnoHo |
| محذوف @milardport RT @NephJC: T2: T2: they looked at urinary creatinine (efigure 3) Seems to be lower with steroids - ? Sarcopenia #NephJc https://t.co/cXkr7chRgc |
 | gub70725 @gub70725 RT @edgarvlermamd: @CJASN Rituximab failed to ⬇️ levels of specific antibodies w/ pathogenetic roles in IgA nephropathy #Nephpearls #NephJC 👉🏼 https://t.co/58ZAerhPMF https://t.co/P2Jb2YCUFH |
| gub70725 @gub70725 RT @rheault_m: @NephRodby CureGN IgA cohort is relatively low risk. (Guess who's on their patient newsletter committee?) #NephJC https://t.co/xpufm6NmE6 https://t.co/O0TxEjpYBR |
| Mo Alzubaidi @NephrosisMo RT @edgarvlermamd: @CJASN IgA Nephropathy: @CJASN IgA Nephropathy: Risk Factors for Progression #Nephpearls #NephJC https://t.co/wwuiVDphpo |
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