#GynCSM Transcript

Healthcare social media transcript of the #GynCSM hashtag.
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See #GynCSM Influencers/Analytics.

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NCI Cancer Stats @NCICancerStats
#UterineCancer is the most common #cancer of the female reproductive system. Learn more here: https://t.co/vmRb0W9SNC #GynCSM https://t.co/lXzCAqr7RF
GYN Cancer | #GYNCSM @gyncsm
Welcome to #gyncsm - a passionate community of gynecologic cancer survivors, caregivers, advocates and health care providers.
Dee Sparacio @womenofteal
RT @gyncsm: Welcome to #gyncsm - a passionate community of gynecologic cancer survivors, caregivers, advocates and health care providers.
GYN Cancer | #GYNCSM @gyncsm
Our co-moderators are @womenofteal @btrfly12 #gyncsm
GYN Cancer | #GYNCSM @gyncsm
Our health care moderators are @ShannonWestin @temkins @journeycancer and our mental health moderator @DrBeckerSchutte #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: Our health care moderators are @ShannonWestin @temkins @journeycancer and our mental health moderator @DrBeckerSchutte #gyncsm
GYN Cancer | #GYNCSM @gyncsm
We start out with brief introโ€™s - Please take a moment to introduce yourself. :) #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: We start out with brief introโ€™s - Please take a moment to introduce yourself. :) #gyncsm
T @trishaannete
RT @NCICancerStats: #UterineCancer is the most common #cancer of the female reproductive system. Learn more here: #UterineCancer is the most common #cancer of the female reproductive system. Learn more here: https://t.co/vmRb0W9SNC #GynCSM https://t.co/lXzCAqr7RF
Dee Sparacio @womenofteal
Dee here! Dx #ovca HGSOC Stage3B 2005, OC research advocate, blogger & co-moderator #gyncsm
Shereese Maynard, MS; MBA ๐Ÿ˜ท She/Her @ShereeseMayMba
Hello all. I'm Shereese. I'll be lurking while working tonight. #gyncsm https://t.co/4QzuuU9AUO
Christina Lizaso @btrfly12
Hi all. I'm Christina Lizaso โ€“ passionate re: community engagement and cancer. Iโ€™ll be moderating as @gyncsm today. #gyncsm
Christina Lizaso @btrfly12
RT @gyncsm: Welcome to #gyncsm - a passionate community of gynecologic cancer survivors, caregivers, advocates and health care providers.
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Hello #gyncsm group! Iโ€™m Ronny Drapkin โ€“ a physician-scientist at @Penn @PennCancer, director of @Penn_OCRC, and director of gyn cancer research @BasserBRCA. Excited to be here!
Dee Sparacio @womenofteal
@ShereesePubHlth Thanks for joining us tonight Shereese! #gyncsm
GYN Cancer | #GYNCSM @gyncsm
If you prefer to listen only during the chat, we'd love for you to tweet "#gyncsm" when you join - just to let us know you are here.
Dee Sparacio @womenofteal
We hope you will take a minute to view this video by @ronny_drapkin which explains BRCA and ovarian cancer https://t.co/ArsKLLZixW #gyncsm
GYN Cancer | #GYNCSM @gyncsm
Pls continue intro's & welcomes - we'll start in w/ the "ground rules" :) and tips! #gyncsm
Erica Bednar @EMBOSU
Hi everyone-excited to join tonight after many missed chats the past several months! I'm Erica, genetic counselor in the Gyn Onc clinics at @MDAndersonNews and @harrishealth LBJ hospital #gyncsm
Christina Lizaso @btrfly12
RT @womenofteal: We hope you will take a minute to view this video by @ronny_drapkin which explains BRCA and ovarian cancer https://t.co/ArsKLLZixW #gyncsm
Dee Sparacio @womenofteal
@EMBOSU @MDAndersonNews @harrishealth Hi Erica-- so glad you can join us tonight. #gyncsm
GYN Cancer | #GYNCSM @gyncsm
The #gyncsm chat promotes community in a public forum. Learn more about risks/benefits: https://t.co/TipZUv1jQy
Lisa M Guzzardi, RN @LguzzardiM
Greetings from NY! Patient advocate & curator of #hereditarycancer journal club here. #gyncsm
Dee Sparacio @womenofteal
#gyncsm tagged resources and referrals are not a substitute for speaking with your doctor who understands your needs and history.
Dee Sparacio @womenofteal
@LguzzardiM Hi Lisa - Thanks for joining us tonight and for Facebook journal club. I learn from it all the time. #gyncsm
Dee Sparacio @womenofteal
Remember- Twitter is an open social network & posts are public.Use a Direct Messages to exchange email addresses/personal info #gyncsm
GYN Cancer | #GYNCSM @gyncsm
Are you new to tweet chats? Follow hashtag #gyncsm and include it in every tweet during the next hour to engage with others about our topic.
Michele Rhee @michelerhee
@gyncsm Hello! Itโ€™s Michele from Boston. Diagnosed with thyroid cancer at 20 & general #AYACancer/#AYACSM & #RareDisease/#RareCancer patient advocate. #gyncsm https://t.co/GEzw94anw3
Dee Sparacio @womenofteal
@michelerhee @gyncsm Welcome Michele Thanks so much for joining in.#gyncsm
Lisa M Guzzardi, RN @LguzzardiM
@womenofteal Pleasure is all mine, your #gyncsm advocacy is deeply admired.
GYN Cancer | #GYNCSM @gyncsm
So happy to have @ronny_drapkin joining us tonight to discuss his research on where and how high-grade serous ovarian cancer originates. #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: So happy to have @ronny_drapkin joining us tonight to discuss his research on where and how high-grade serous ovarian cancer originates. #gyncsm
Catherine Gegaris @cgegaris1
@gyncsm #gyncsm
GYN Cancer | #GYNCSM @gyncsm
We also welcome all those โ€œlistening inโ€. You can always tweet us or email us with questions/comments after the chat is over. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Thanks for the invite. Excited to be here! #gyncsm
Dee Sparacio @womenofteal
Thank you to all who have tweeted during the past month with the #gyncsm hashtag and especially those who RT'd about this chat. #gyncsm
GYN Cancer | #GYNCSM @gyncsm
Tonight on #gyncsm we are discussing research into the origin of high-grade serous ovarian cancer. Moderator note: weโ€™ll be using HGSOC during this #gyncsm chat to stand for high-grade serous ovarian cancer.
Amanda Crowell Itliong @MIShouldTalk
Hey #gyncsm crew! Iโ€™m Amanda from MI. Patient and advocate with low grade ovarian cancer and always looking to learn more about all cancers
Dee Sparacio @womenofteal
@MIShouldTalk Great to have you Amanda ! #gyncsm
GYN Cancer | #GYNCSM @gyncsm
Weโ€™ll use a Topic format with T1:, T2:, etc. posed from this handle. Include the corresponding T1:, T2:, etc. at the front of your answer/comment. There are 5 Topic questions tonight followed by a Today I Learned (TIL) segment. #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: Weโ€™ll use a Topic format with T1:, T2:, etc. posed from this handle. Include the corresponding T1:, T2:, etc. at the front of your answer/comment. There are 5 Topic questions tonight followed by a Today I Learned (TIL) segment. #gyncsm
Erica Bednar @EMBOSU
RT @gyncsm: Tonight on #gyncsm we are discussing research into the origin of high-grade serous ovarian cancer. Moderator note: weโ€™ll be using HGSOC during this #gyncsm chat to stand for high-grade serous ovarian cancer.
GYN Cancer | #GYNCSM @gyncsm
You can find a list of the upcoming topic questions on our #gyncsm blog page: https://t.co/q3ZnHiAGvI
Dee Sparacio @womenofteal
RT @gyncsm: You can find a list of the upcoming topic questions on our #gyncsm blog page: You can find a list of the upcoming topic questions on our #gyncsm blog page: https://t.co/q3ZnHiAGvI
Christina Lizaso @btrfly12
RT @gyncsm: You can find a list of the upcoming topic questions on our #gyncsm blog page: You can find a list of the upcoming topic questions on our #gyncsm blog page: https://t.co/q3ZnHiAGvI
GYN Cancer | #GYNCSM @gyncsm
Before we dive into the topics, @ronny_drapkin, can you share a little bit about what led you to study ovarian cancer and also a little about your lab in terms of its size and research focus? #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: Before we dive into the topics, @ronny_drapkin, can you share a little bit about what led you to study ovarian cancer and also a little about your lab in terms of its size and research focus? #gyncsm
Dee Sparacio @womenofteal
Welcome @cawincolumbia and @cgregaris ! Thanks for joining us. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Iโ€™ll reply with points 1 (1/2): When I was a postdoc @DanaFarber, I worked in a lab that focused on the function of BRCA1. However, most of the effort was in breast cancer but I knew that BRCA1 was a tumor-suppressor for both ovarian and breast cancers. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
(2/2) My mentor, David Livingston, gave me the latitude to do research in ovarian cancer and I began by focusing on a biomarker for early detection and thinking about pathogenesis. #gyncsm
Michele Rhee @michelerhee
@womenofteal @gyncsm Iโ€™m so happy I could make it this week! #gyncsm https://t.co/NtwddEeXhs
Christina Lizaso @btrfly12
RT @ronny_drapkin: Iโ€™ll reply with points 1 (1/2): Iโ€™ll reply with points 1 (1/2): When I was a postdoc @DanaFarber, I worked in a lab that focused on the function of BRCA1. However, most of the effort was in breast cancer but I knew that BRCA1 was a tumor-suppressor for both ovarian and breast cancers. #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: (2/2) My mentor, David Livingston, gave me the latitude to do research in ovarian cancer and I began by focusing on a biomarker for early detection and thinking about pathogenesis. #gyncsm
GYN Cancer | #GYNCSM @gyncsm
Of the 4 main OC types, most #ovariancancer (85-90%) falls into the Epithelial type. High-grade serous (HGSOC) is the most common subtype of ovarian cancer, making up ~75% of Epithelial ovarian cancer, which includes fallopian tube cancer and primary peritoneal cancer. #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: Of the 4 main OC types, most #ovariancancer (85-90%) falls into the Epithelial type. High-grade serous (HGSOC) is the most common subtype of ovarian cancer, making up ~75% of Epithelial ovarian cancer, which includes fallopian tube cancer and primary peritoneal cancer. #gyncsm
GYN Cancer | #GYNCSM @gyncsm
Here comes Topic 1 (T1:)... #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
My lab is made up of students, postdoctoral fellows, and physician-scientists. There are about 7-10 people in the lab at any one time. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: My lab is made up of students, postdoctoral fellows, and physician-scientists. There are about 7-10 people in the lab at any one time. #gyncsm
Erica Bednar @EMBOSU
RT @gyncsm: Of the 4 main OC types, most #ovariancancer (85-90%) falls into the Epithelial type. High-grade serous (HGSOC) is the most common subtype of ovarian cancer, making up ~75% of Epithelial ovarian cancer, which includes fallopian tube cancer and primary peritoneal cancer. #gyncsm
GYN Cancer | #GYNCSM @gyncsm
T1: What makes HGSOC different from other sub-types in terms of the tumor itself, how it spreads, how it is treated, and its prognosis? #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: T1: T1: What makes HGSOC different from other sub-types in terms of the tumor itself, how it spreads, how it is treated, and its prognosis? #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 1 (1/2): HGSOC is the most common subtype of ovarian cancer. Unfortunately, it tends to spread before detection. Once it is diagnosed, most patients get treated with surgery and chemotherapy. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 2 (2/2): Initially, the majority of patients will have a positive response to the treatment. Unfortunately, most will have their tumors come back. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 1 (1/2): Point 1 (1/2): HGSOC is the most common subtype of ovarian cancer. Unfortunately, it tends to spread before detection. Once it is diagnosed, most patients get treated with surgery and chemotherapy. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 2 (2/2): Point 2 (2/2): Initially, the majority of patients will have a positive response to the treatment. Unfortunately, most will have their tumors come back. #gyncsm
Dawn Ford @tealbtrflies4me
RT @gyncsm: Tonight on #gyncsm we are discussing research into the origin of high-grade serous ovarian cancer. Moderator note: weโ€™ll be using HGSOC during this #gyncsm chat to stand for high-grade serous ovarian cancer.
Lisa M Guzzardi, RN @LguzzardiM
RT @gyncsm: Of the 4 main OC types, most #ovariancancer (85-90%) falls into the Epithelial type. High-grade serous (HGSOC) is the most common subtype of ovarian cancer, making up ~75% of Epithelial ovarian cancer, which includes fallopian tube cancer and primary peritoneal cancer. #gyncsm
GYN Cancer | #GYNCSM @gyncsm
T2: When did research start pointing to the fallopian tubes as the origin site of HGSOC? #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: T2: T2: When did research start pointing to the fallopian tubes as the origin site of HGSOC? #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 1 (1/4): After the BRCA genes were cloned in the mid-1990s, we began offering women at risk prophylactic surgery. That included mastectomy for breast cancer and removal of the ovaries (and fallopian tubes) for ovarian cancer. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 1 (1/4): Point 1 (1/4): After the BRCA genes were cloned in the mid-1990s, we began offering women at risk prophylactic surgery. That included mastectomy for breast cancer and removal of the ovaries (and fallopian tubes) for ovarian cancer. #gyncsm
Lisa M Guzzardi, RN @LguzzardiM
@ronny_drapkin Due to often late staged diagnosis, is that correct @ronny_drapkin ? #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 2 (2/4): The removal of the FTs along with the ovaries was surgically convenient and most of the attention was placed on the ovary. As early as 2000, reports began to emerge that some of these prophylactic specimens had abnormal looking cells in the FT. #gyncsm
Lisa M Guzzardi, RN @LguzzardiM
RT @ronny_drapkin: Point 2 (2/4): Point 2 (2/4): The removal of the FTs along with the ovaries was surgically convenient and most of the attention was placed on the ovary. As early as 2000, reports began to emerge that some of these prophylactic specimens had abnormal looking cells in the FT. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@LguzzardiM #gyncsm Yes, diagnosis is often late stage when tumor has metastasized.
Dee Sparacio @womenofteal
FT = Fallopian Tubes HGSOC= High Grade Serous Ovarian Cancer #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 2 (2/4): Point 2 (2/4): The removal of the FTs along with the ovaries was surgically convenient and most of the attention was placed on the ovary. As early as 2000, reports began to emerge that some of these prophylactic specimens had abnormal looking cells in the FT. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 3 (3/4): Around 2005-2006, Dr. Chris Crum (my clinical mentor during residency) @BrighamWomens developed the SEE-FIM (Sectioning and Extensively Examining the FIMbriated end of the fallopian tube) protocol to get a better understanding of what was happening there. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 4 (4/4): That is when we realized that most of these tumors were arising from the tube rather than the ovary. Subsequent use of SEE-FIM confirmed this in publications around the world. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 3 (3/4): Point 3 (3/4): Around 2005-2006, Dr. Chris Crum (my clinical mentor during residency) @BrighamWomens developed the SEE-FIM (Sectioning and Extensively Examining the FIMbriated end of the fallopian tube) protocol to get a better understanding of what was happening there. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 4 (4/4): Point 4 (4/4): That is when we realized that most of these tumors were arising from the tube rather than the ovary. Subsequent use of SEE-FIM confirmed this in publications around the world. #gyncsm
Christina Lizaso @btrfly12
T2: The first I heard about the fallopian tube as possible origin site for #ovariancancer was around 2010 I think... so thinking the studies are maturing and diving deeper and starting to influence practice.... #gyncsm
Dee Sparacio @womenofteal
The development of SEE-FIM protocol was crucial to your research. I saw that a Team in Thailand recently confirmed benefit of its use. https://t.co/hPdUU1IGb0 #gyncsm
GYN Cancer | #GYNCSM @gyncsm
T3: What characteristics did you study when you examined fallopian tube lesions versus lesions of the ovary? How are BRCA mutations involved? #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@btrfly12 #gyncsm In retrospect, the earliest published studies were in 2000-2001. It wasn't until after SEE-FIM that we realized what was happening and appreciated those earlier studies.
Christina Lizaso @btrfly12
RT @ronny_drapkin: @btrfly12 #gyncsm In retrospect, the earliest published studies were in 2000-2001. It wasn't until after SEE-FIM that we realized what was happening and appreciated those earlier studies.
Sarah Temkin @temkins
The majority of #ovariancancer is diagnosed at Stage III or IV. To date a mode of screening or early detection which decreases #cancermortality has not been identified. This is why prevention is so important to this disease. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Iโ€™ll start my reply with point 1 (1/6): Much of that data is based on histological studies. We wanted to see if we could definitively show that these tumors arise from precursor lesions in the FTs by using next generation sequencing and advanced bioinformatic tools. #gyncsm
Kristel Gonzalez @Kristel_GT
RT @EMBOSU: Hi everyone-excited to join tonight after many missed chats the past several months! I'm Erica, genetic counselor in the Gyn Onc clinics at @MDAndersonNews and @harrishealth LBJ hospital #gyncsm
Dee Sparacio @womenofteal
@ronny_drapkin Curious Is SEE-FIM protocol freely available to all researchers around the world? #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: T3: T3: What characteristics did you study when you examined fallopian tube lesions versus lesions of the ovary? How are BRCA mutations involved? #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Iโ€™ll start my reply with point 1 (1/6): Iโ€™ll start my reply with point 1 (1/6): Much of that data is based on histological studies. We wanted to see if we could definitively show that these tumors arise from precursor lesions in the FTs by using next generation sequencing and advanced bioinformatic tools. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 2 (2/6): We identified cases of HGSOC that had precursors identified in the FT by pathologists. We then used laser-capture microdissection to carefully isolate those cells and applied whole-exome sequencing to characterize the mutations and copy number changes. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 2 (2/6): Point 2 (2/6): We identified cases of HGSOC that had precursors identified in the FT by pathologists. We then used laser-capture microdissection to carefully isolate those cells and applied whole-exome sequencing to characterize the mutations and copy number changes. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@womenofteal #gyncsm It is a simple procedure done in the Pathology department when prophylactic specimens are examined and processed for microscopic evaluation.
Michele Rhee @michelerhee
@temkins What are the recommendations for prevention of #ovariancancer? #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 3 (3/6): These efforts revealed that mutations in p53 are among the earliest defects detectable. We also found that copy number alterations (amplifications or deletions in certain genes or chromosomal regions) are also frequent, early, and involve the BRCA genes. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 3 (3/6): Point 3 (3/6): These efforts revealed that mutations in p53 are among the earliest defects detectable. We also found that copy number alterations (amplifications or deletions in certain genes or chromosomal regions) are also frequent, early, and involve the BRCA genes. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 4 (4/6): As lesions become more complex they retain the early defects (p53 mutations and copy number changes) and acquire additional ones. #gyncsm
GYN Cancer | #GYNCSM @gyncsm
#gyncsm moderator note: just a reminder we are using HGSOC as abbreviation for High-Grade Serous Ovarian Cancer
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 5 (5/6): Using computational tools we were able to develop a molecular clock. This approach showed that there are 6-7 years between the development of a precursor lesion (called a STIC) and clinically evident 'ovarian' cancer. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 4 (4/6): Point 4 (4/6): As lesions become more complex they retain the early defects (p53 mutations and copy number changes) and acquire additional ones. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 6 (6/6): However, once the tumor cells get to the ovary, there are only 1.9 years before they spread to the rest of the abdominal cavity. Hence, the window of opportunity to intervene is the 6-7 years before the cells get to the ovary. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 5 (5/6): Point 5 (5/6): Using computational tools we were able to develop a molecular clock. This approach showed that there are 6-7 years between the development of a precursor lesion (called a STIC) and clinically evident 'ovarian' cancer. #gyncsm
Erica Bednar @EMBOSU
This is one of my favorite diagrams to help visually understand how the fallopian tube may be involved in HGSOC development #gyncsm (From article by @MDAndersonNews colleagues https://t.co/IDr3dbcDae) https://t.co/DDu6TxwXy4
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 6 (6/6): Point 6 (6/6): However, once the tumor cells get to the ovary, there are only 1.9 years before they spread to the rest of the abdominal cavity. Hence, the window of opportunity to intervene is the 6-7 years before the cells get to the ovary. #gyncsm
Lisa M Guzzardi, RN @LguzzardiM
Whatโ€™s new in biomarker testing for #ovariancancer? #gyncsm #womenshealth #genetics #earlydetection https://t.co/fysMPyh7wF
Dee Sparacio @womenofteal
RT @EMBOSU: This is one of my favorite diagrams to help visually understand how the fallopian tube may be involved in HGSOC development #gyncsm (From article by @MDAndersonNews colleagues https://t.co/IDr3dbcDae) https://t.co/DDu6TxwXy4
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@michelerhee @temkins #gyncsm we'll get to that shortly!
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@temkins #gyncsm Correct. More on that shortly.
Dee Sparacio @womenofteal
@ronny_drapkin I often wondered how long from those first precancerous cells it took to develop into cancer. #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: Point 6 (6/6): Point 6 (6/6): However, once the tumor cells get to the ovary, there are only 1.9 years before they spread to the rest of the abdominal cavity. Hence, the window of opportunity to intervene is the 6-7 years before the cells get to the ovary. #gyncsm
Christina Lizaso @btrfly12
RT @EMBOSU: This is one of my favorite diagrams to help visually understand how the fallopian tube may be involved in HGSOC development #gyncsm (From article by @MDAndersonNews colleagues https://t.co/IDr3dbcDae) https://t.co/DDu6TxwXy4
Christina Lizaso @btrfly12
Love the idea of finding a way to catch the pre-cancerous cells like we can already do in #cervicalcancer #gyncsm
Dee Sparacio @womenofteal
@btrfly12 Me too! #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
This is what the SEE-FIM protocol looks like (after a pathologist processes the FT) #gyncsm https://t.co/8kvPXBwQeC
GYN Cancer | #GYNCSM @gyncsm
T4a: Are HGSOC cancer cells found in the fallopian tube different than those found in/on the ovary? How do they differ from Fallopian Tube Cancer cells? #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@btrfly12 #gyncsm Yes!
Dee Sparacio @womenofteal
RT @ronny_drapkin: This is what the SEE-FIM protocol looks like (after a pathologist processes the FT) #gyncsm https://t.co/8kvPXBwQeC
GYN Cancer | #GYNCSM @gyncsm
#gyncsm moderator note: and we are using FT for Fallopian Tube
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
This is what the FT precursors look like #gyncsm https://t.co/6YNO16pYx7
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
T4: While there have been many efforts to find early cancer cells in/on the ovary, no one has been able to reproducibly identify them. Since SEE-FIM, a number of systematic attempts have tried to find early precursors in the ovary but have failed. #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: #gyncsm moderator note: and we are using FT for Fallopian Tube
Dee Sparacio @womenofteal
RT @ronny_drapkin: This is what the FT precursors look like #gyncsm https://t.co/6YNO16pYx7
GYN Cancer | #GYNCSM @gyncsm
T4b: Patients/survivors/others - Have your (or someone's you are involved w/) pathology reports shown cancer cells in the fallopian tubes? #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: T4: T4: While there have been many efforts to find early cancer cells in/on the ovary, no one has been able to reproducibly identify them. Since SEE-FIM, a number of systematic attempts have tried to find early precursors in the ovary but have failed. #gyncsm
Michele Rhee @michelerhee
@womenofteal @btrfly12 Yes!! Earlier diagnosis matters. If people arenโ€™t diagnosed until disease has progressed to a late stage, then *of course* itโ€™s so much harder to treat. #gyncsm
mary @zebrafinch
RT @gyncsm: You can find a list of the upcoming topic questions on our #gyncsm blog page: You can find a list of the upcoming topic questions on our #gyncsm blog page: https://t.co/q3ZnHiAGvI
mary @zebrafinch
RT @gyncsm: Tonight on #gyncsm we are discussing research into the origin of high-grade serous ovarian cancer. Moderator note: weโ€™ll be using HGSOC during this #gyncsm chat to stand for high-grade serous ovarian cancer.
Dee Sparacio @womenofteal
@gyncsm My pathology report did not show cancer in my FT but I wonder if they were examined with SEE-FIM if cancer cells would be found. Dx 2005 #gyncsm
GYN Cancer | #GYNCSM @gyncsm
About to move into our last general topic area - with 3 sub-questions... #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@gyncsm #gyncsm I know that @Penn and @BrighamWomens the pathology reports include the mention of 'serous tubal intraepithelial carcinoma' (STIC) if they see the lesion in the FT.
mary @zebrafinch
RT @gyncsm: We also welcome all those โ€œlistening inโ€. You can always tweet us or email us with questions/comments after the chat is over. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: @gyncsm #gyncsm I know that @Penn and @BrighamWomens the pathology reports include the mention of 'serous tubal intraepithelial carcinoma' (STIC) if they see the lesion in the FT.
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@womenofteal @gyncsm #gyncsm Probably not. The SEE-FIM paper was published in 2007.
GYN Cancer | #GYNCSM @gyncsm
T5: As we look to the future: How will knowledge of where a majority of ovarian cancers originate impact women at increased risk? How might this research help in the development of an early detection test? What is the impact for women diagnosed with ovarian cancer? #gyncsm
Shereese Maynard, MS; MBA ๐Ÿ˜ท She/Her @ShereeseMayMba
RT @ronny_drapkin: @womenofteal @gyncsm #gyncsm Probably not. The SEE-FIM paper was published in 2007.
Dee Sparacio @womenofteal
RT @gyncsm: T5: T5: As we look to the future: How will knowledge of where a majority of ovarian cancers originate impact women at increased risk? How might this research help in the development of an early detection test? What is the impact for women diagnosed with ovarian cancer? #gyncsm
Shereese Maynard, MS; MBA ๐Ÿ˜ท She/Her @ShereeseMayMba
RT @gyncsm: About to move into our last general topic area - with 3 sub-questions... #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
T5: Iโ€™ll answer with a few points (1/4): Tremendous potential here! The most obvious areas will be in prevention and early detection. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 2 (2/4): The significant morbidity associated with removal of the FTs and ovaries (surgical menopause) has led up to 30-40% of BRCA carriers to delay or refuse risk-reducing surgery. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: T5: Iโ€™ll answer with a few points (1/4): T5: Iโ€™ll answer with a few points (1/4): Tremendous potential here! The most obvious areas will be in prevention and early detection. #gyncsm
Christina Lizaso @btrfly12
RT @gyncsm: T5: T5: As we look to the future: How will knowledge of where a majority of ovarian cancers originate impact women at increased risk? How might this research help in the development of an early detection test? What is the impact for women diagnosed with ovarian cancer? #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 2 (2/4): Point 2 (2/4): The significant morbidity associated with removal of the FTs and ovaries (surgical menopause) has led up to 30-40% of BRCA carriers to delay or refuse risk-reducing surgery. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 3 (3/4): For these women, there are ongoing studies looking at the effect of removing the FTs first (interval salpingectomy) and later removing the ovaries (delayed oophorectomy). One example is the WISP study by @KarenLuMD #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 3 (3/4): Point 3 (3/4): For these women, there are ongoing studies looking at the effect of removing the FTs first (interval salpingectomy) and later removing the ovaries (delayed oophorectomy). One example is the WISP study by @KarenLuMD #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Point 4 (4/4): For average risk women there is โ€˜opportunistic salpingectomyโ€™ - for example, if you are having a hysterectomy for any reason, the rec is to remove the FTs #gyncsm
Erica Bednar @EMBOSU
@ronny_drapkin @gyncsm @Penn @BrighamWomens I've seen a few reports at MD Anderson where we have detected STIC...always very interesting especially since most women are diagnosed with HGSOC at an advanced stage, we rarely have the chance to see such an early presentation of FT/HGSOC #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: Point 2 (2/4): Point 2 (2/4): The significant morbidity associated with removal of the FTs and ovaries (surgical menopause) has led up to 30-40% of BRCA carriers to delay or refuse risk-reducing surgery. #gyncsm
Sarah Temkin @temkins
A5: For patients it's important to know that ovarian, fallopian tube and primary peritoneal high grade serous cancers are considered the same disease for the purpose of treatment #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: Point 3 (3/4): Point 3 (3/4): For these women, there are ongoing studies looking at the effect of removing the FTs first (interval salpingectomy) and later removing the ovaries (delayed oophorectomy). One example is the WISP study by @KarenLuMD #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: Point 4 (4/4): Point 4 (4/4): For average risk women there is โ€˜opportunistic salpingectomyโ€™ - for example, if you are having a hysterectomy for any reason, the rec is to remove the FTs #gyncsm
Lisa M Guzzardi, RN @LguzzardiM
@gyncsm Iโ€™ve seen a few #BRCA + women who had a risk โฌ‡๏ธ BSO with path reports revealing early staged Fallopian tube cancers. Life saving surgery indeed! @ronny_drapkin do you know if somatic testing has revealed other mutations ? Is this being done? Inquiring minds wanna know #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: Point 4 (4/4): Point 4 (4/4): For average risk women there is โ€˜opportunistic salpingectomyโ€™ - for example, if you are having a hysterectomy for any reason, the rec is to remove the FTs #gyncsm
Christina Lizaso @btrfly12
RT @temkins: A5: A5: For patients it's important to know that ovarian, fallopian tube and primary peritoneal high grade serous cancers are considered the same disease for the purpose of treatment #gyncsm
Dee Sparacio @womenofteal
RT @temkins: A5: A5: For patients it's important to know that ovarian, fallopian tube and primary peritoneal high grade serous cancers are considered the same disease for the purpose of treatment #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@EMBOSU @gyncsm @Penn @BrighamWomens #gyncsm STIC 'in isolation' are only likely to be seen in BRCA1/2 mutation carriers. The frequency of identifying a STIC-alone (no HGSOC) is ~4-5% of RRSOs
Dee Sparacio @womenofteal
@ronny_drapkin @gyncsm How are BRCA and other mutations involved in these FT lesions? #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: @EMBOSU @gyncsm @Penn @BrighamWomens #gyncsm STIC 'in isolation' are only likely to be seen in BRCA1/2 mutation carriers. The frequency of identifying a STIC-alone (no HGSOC) is ~4-5% of RRSOs
Michele Rhee @michelerhee
@ronny_drapkin For average or low risk women, is there anything other than opportunistic FT removal as a preventative measure re: #ovariancancer? #gyncsm
Lisa M Guzzardi, RN @LguzzardiM
RT @ronny_drapkin: @EMBOSU @gyncsm @Penn @BrighamWomens #gyncsm STIC 'in isolation' are only likely to be seen in BRCA1/2 mutation carriers. The frequency of identifying a STIC-alone (no HGSOC) is ~4-5% of RRSOs
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@LguzzardiM @gyncsm #gyncsm Yes. First, all women with HGSOC are now recommended for testing. Second, in addition to BRCA1 and BRCA2 there are other genes, like RAD51C, that are associated with risk. We don't know as much about these genes though.
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@temkins #gyncsm Indeed - pathologically, they are the same disease too!
Erica Bednar @EMBOSU
Learn more about WISP here: https://t.co/rSkggrXgJb #gyncsm #gencsm #BRCA #LynchSyndrome #HereditaryCancer #previvors
Lisa M Guzzardi, RN @LguzzardiM
RT @ronny_drapkin: @LguzzardiM @gyncsm #gyncsm Yes. First, all women with HGSOC are now recommended for testing. Second, in addition to BRCA1 and BRCA2 there are other genes, like RAD51C, that are associated with risk. We don't know as much about these genes though.
Christina Lizaso @btrfly12
RRSOs = Risk-reducing salpingo-oophorectomy = high risk but not cancer yet removal of ovaries and fallopian tubes #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@womenofteal @gyncsm #gyncsm The BRCA genes are involved in maintaining genomic stability. They repair our DNA. When they are mutated or lost, we have genomic INstability. That leads to cancer.
Dee Sparacio @womenofteal
@ronny_drapkin @temkins I knew they were treated the same but did not know they were the same pathologically. Just assumed there was something different about them. #gyncsm
GYN Cancer | #GYNCSM @gyncsm
#gyncsm:
Dee Sparacio @womenofteal
RT @EMBOSU: Learn more about WISP here: Learn more about WISP here: https://t.co/rSkggrXgJb #gyncsm #gencsm #BRCA #LynchSyndrome #HereditaryCancer #previvors
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@michelerhee #gyncsm Great question. The risk of ovarian cancer is pretty low for average risk women. Sadly, we currently do not have a test for early detection.
GYN Cancer | #GYNCSM @gyncsm
Moderator note... we are continuing on our last topic area: How will knowledge of where a majority of ovca originate impact women at increased risk? How might this research help in the development of an early detection test? What is the impact for women diagnosed w/ ovca?#gyncsm
GYN Cancer | #GYNCSM @gyncsm
#gyncsm
Erica Bednar @EMBOSU
@michelerhee knowing/learning about your family history of cancer is an important piece of knowing if you may be in the higher vs average risk population. Family history of ovarian cancer can lead to recommendations of genetic counseling, testing, screening #gyncsm
Dee Sparacio @womenofteal
@ronny_drapkin @gyncsm Your article in Nature https://t.co/vBVdQSVod6 about your research talks about TP53. How was that mutation important in your research? #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
T6: This is the most exciting part. How does the FT matter!?! Lots of activity in this area. We are actively working with a company (nVision Medical) that has developed a modified hysteroscope that can sample the cells in the FT. It is like a pap smear of the FT. #gyncsm
Sarah Temkin @temkins
@michelerhee @ronny_drapkin 5 years of oral contraceptive use decreases risk of #ovariancancer by 50%. #gyncsm. This is true for women at average and high risk of disease. #gyncsm.
Dee Sparacio @womenofteal
RT @ronny_drapkin: T6: T6: This is the most exciting part. How does the FT matter!?! Lots of activity in this area. We are actively working with a company (nVision Medical) that has developed a modified hysteroscope that can sample the cells in the FT. It is like a pap smear of the FT. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@womenofteal @gyncsm #gyncsm TP53 is a tumor suppressor that is often called the 'Guardian of the Genome'. The loss of TP53 function early in the development of these cancers (along with BRCA) leads to the genomic instability that is the hallmark of HGSOC.
Lisa M Guzzardi, RN @LguzzardiM
Womenโ€™s cancers: how the discovery of #BRCA genes is driving current concepts of #cancer biology and therapeutics โฆ@nyulangoneโฉ #gyncsm #womenshealth #genetics #OvarianCancer #hereditarycancer https://t.co/t0O7vsTn7N
Sarah Temkin @temkins
@michelerhee @ronny_drapkin 5 years of oral contraceptive use decreases risk of #ovariancancer by 50%. #gyncsm. This is true for women at average and high risk of disease.
Dee Sparacio @womenofteal
@ronny_drapkin WOW ! Great to hear this development. #gyncsm
Sarah Temkin @temkins
RT @EMBOSU: @michelerhee knowing/learning about your family history of cancer is an important piece of knowing if you may be in the higher vs average risk population. Family history of ovarian cancer can lead to recommendations of genetic counseling, testing, screening #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: @womenofteal @gyncsm #gyncsm TP53 is a tumor suppressor that is often called the 'Guardian of the Genome'. The loss of TP53 function early in the development of these cancers (along with BRCA) leads to the genomic instability that is the hallmark of HGSOC.
Lisa M Guzzardi, RN @LguzzardiM
RT @ronny_drapkin: T6: T6: This is the most exciting part. How does the FT matter!?! Lots of activity in this area. We are actively working with a company (nVision Medical) that has developed a modified hysteroscope that can sample the cells in the FT. It is like a pap smear of the FT. #gyncsm
Dee Sparacio @womenofteal
RT @LguzzardiM: Womenโ€™s cancers: Womenโ€™s cancers: how the discovery of #BRCA genes is driving current concepts of #cancer biology and therapeutics โฆ@nyulangoneโฉ #gyncsm #womenshealth #genetics #OvarianCancer #hereditarycancer https://t.co/t0O7vsTn7N
Lisa M Guzzardi, RN @LguzzardiM
RT @ronny_drapkin: @womenofteal @gyncsm #gyncsm TP53 is a tumor suppressor that is often called the 'Guardian of the Genome'. The loss of TP53 function early in the development of these cancers (along with BRCA) leads to the genomic instability that is the hallmark of HGSOC.
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
T6: the goal of such a device/method is to detect early FT cancers before they get to the ovary. We are currently testing it in women with pelvic masses but we are already planning to test it in BRCA mutation carriers. #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: T6: T6: the goal of such a device/method is to detect early FT cancers before they get to the ovary. We are currently testing it in women with pelvic masses but we are already planning to test it in BRCA mutation carriers. #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: T6: T6: This is the most exciting part. How does the FT matter!?! Lots of activity in this area. We are actively working with a company (nVision Medical) that has developed a modified hysteroscope that can sample the cells in the FT. It is like a pap smear of the FT. #gyncsm
GYN Cancer | #GYNCSM @gyncsm
Learning so much tonight. Thanks to our guest and thanks to all for joining in for more of an Ask the Expert type chat vs. broad open discussion. Hope you enjoyed it. We like to mix it up. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
T6: Another approach relates to the concept of 'tissue proximal sampling'. This means that if we can get closer to the source of the cancer, perhaps we can detect it earlier. Efforts from @HopkinsMedicine are resulting in exciting results with a PapSeek test. #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: Learning so much tonight. Thanks to our guest and thanks to all for joining in for more of an Ask the Expert type chat vs. broad open discussion. Hope you enjoyed it. We like to mix it up. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
T6: PapSeek uses a regular endocervical pap brush to collect cells and determine if they harbor molecular defects of ovarian cancer. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: T6: T6: Another approach relates to the concept of 'tissue proximal sampling'. This means that if we can get closer to the source of the cancer, perhaps we can detect it earlier. Efforts from @HopkinsMedicine are resulting in exciting results with a PapSeek test. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: T6: T6: PapSeek uses a regular endocervical pap brush to collect cells and determine if they harbor molecular defects of ovarian cancer. #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: T6: T6: Another approach relates to the concept of 'tissue proximal sampling'. This means that if we can get closer to the source of the cancer, perhaps we can detect it earlier. Efforts from @HopkinsMedicine are resulting in exciting results with a PapSeek test. #gyncsm
drmalinowski @drmalinowski
RT @temkins: A5: A5: For patients it's important to know that ovarian, fallopian tube and primary peritoneal high grade serous cancers are considered the same disease for the purpose of treatment #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: T6: T6: PapSeek uses a regular endocervical pap brush to collect cells and determine if they harbor molecular defects of ovarian cancer. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
#gyncsm We have a phase II clinical trial open at UPenn (and other place) looking at the utility of this device. Very exciting!
Dee Sparacio @womenofteal
@ronny_drapkin This almost 14 yr HGSOC survivor thanks you for your research and appreciate you taking time to join our community tonight. #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: #gyncsm We have a phase II clinical trial open at UPenn (and other place) looking at the utility of this device. Very exciting!
Christina Lizaso @btrfly12
TIL: That things are starting to come together to make some great head-way in high-grade serous #ovariancancer. Every piece of the puzzle helps reveal new areas to study. #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@womenofteal #gyncsm Thank you for hosting this forum and giving me the opportunity to participate!
Dee Sparacio @womenofteal
Agree! #gyncsm
Christina Lizaso @btrfly12
TIL: Tonight I also re-learned that I LOVE when we have researchers join the chat and that first time tweet chat guests can rock it out! Great job @ronny_drapkin #gyncsm
Erica Bednar @EMBOSU
TIL the time it takes from STIC to development of HGSOC...exciting "window of opportunity" for ovarian cancer prevention and early detection, especially for women with inherited risks where the current risk reduction option= surgery...hopefully more options in future! #gyncsm
Dee Sparacio @womenofteal
RT @EMBOSU: TIL the time it takes from STIC to development of HGSOC...exciting "window of opportunity" for ovarian cancer prevention and early detection, especially for women with inherited risks where the current risk reduction option= surgery...hopefully more options in future! #gyncsm
GYN Cancer | #GYNCSM @gyncsm
Save the Date! Join us on Wednesday, May 8th at 9pmET for our discussion on Supplements/Vitamins - Are they helpful? #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: Save the Date! Join us on Wednesday, May 8th at 9pmET for our discussion on Supplements/Vitamins - Are they helpful? #gyncsm
Dee Sparacio @womenofteal
Remember to check https://t.co/Df2f7Okp35 for a transcript of the chat and resources . #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
I truly believe that efforts geared towards prevention and early detection stand the best chance of reducing mortality (and morbidity) from this disease. Now that we know where to look (the FT), I hope that process will be more rapid. #gyncsm
Christina Lizaso @btrfly12
Any last thoughts on "What is the impact for women already diagnosed with ovarian cancer?" #gyncsm
Christina Lizaso @btrfly12
RT @EMBOSU: TIL the time it takes from STIC to development of HGSOC...exciting "window of opportunity" for ovarian cancer prevention and early detection, especially for women with inherited risks where the current risk reduction option= surgery...hopefully more options in future! #gyncsm
Dee Sparacio @womenofteal
RT @ronny_drapkin: I truly believe that efforts geared towards prevention and early detection stand the best chance of reducing mortality (and morbidity) from this disease. Now that we know where to look (the FT), I hope that process will be more rapid. #gyncsm
Sarah Temkin @temkins
RT @ronny_drapkin: I truly believe that efforts geared towards prevention and early detection stand the best chance of reducing mortality (and morbidity) from this disease. Now that we know where to look (the FT), I hope that process will be more rapid. #gyncsm
Christina Lizaso @btrfly12
RT @ronny_drapkin: I truly believe that efforts geared towards prevention and early detection stand the best chance of reducing mortality (and morbidity) from this disease. Now that we know where to look (the FT), I hope that process will be more rapid. #gyncsm
Erica Bednar @EMBOSU
Nice chatting with you all this evening! Thanks for hosting another great discussion @gyncsm and for sharing so much information @ronny_drapkin! #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
@btrfly12 #gyncsm Thank you @btrfly12 !!๐Ÿ˜€
GYN Cancer | #GYNCSM @gyncsm
Thanks again to all. As always, remember to tweet things of interest with hashtag #gyncsm to keep the conversation going between chats.
GYN Cancer | #GYNCSM @gyncsm
Remember to check our blog https://t.co/oJ3xer6G8t for a transcript of the chat and resources. [ shout-out to @womenofteal for all her work on this! ] #gyncsm
Dee Sparacio @womenofteal
@btrfly12 I think the impact may be on their daughters and sisters. Knowing where to look to catch the cancer early. #gyncsm
Dee Sparacio @womenofteal
RT @gyncsm: Thanks again to all. As always, remember to tweet things of interest with hashtag #gyncsm to keep the conversation going between chats.
Lisa M Guzzardi, RN @LguzzardiM
TIL how promising research being spearheaded by @ronny_drapkinโ€™s lab & others around the country offer much hope that we will have viable early detection #OvarianCancer methods available so that a cure becomes a reality & no longer progresses to late staged disease. #gyncsm
Dee Sparacio @womenofteal
And a special thanks to @btrfly12 for keeping the chat flowing smoothly. You're the best! #gyncsm
Ronny Drapkin ๐Ÿ‡ฎ๐Ÿ‡ฑ ๐Ÿ‡บ๐Ÿ‡ธ @ronny_drapkin
Really enjoyed my first Tweet Chat with #gyncsm. Thank you @btrfly12 and @womenofteal for the invitation!
GYN Cancer | #GYNCSM @gyncsm
As always, we are grateful to the healthcare moderators of #gyncsm for their guidance, participation and support: @ShannonWestin @temkins @journeycancer @DrBeckerSchutte
GYN Cancer | #GYNCSM @gyncsm
Have a wonderful evening all. Hope to see you on more 2nd Wednesdays at 9pmET for our #gyncsm discussions.
Dee Sparacio @womenofteal
RT @gyncsm: Have a wonderful evening all. Hope to see you on more 2nd Wednesdays at 9pmET for our #gyncsm discussions.
GYN Cancer | #GYNCSM @gyncsm
Thank you @ronny_drapkin for giving of your time to our #gyncsm chat and for all you do for the women impacted by gyn cancers.
Dr. Grace Campbell, PhD, MSW, RN, CRRN, FARN @GraceCampbellRN
#gyncsm sorry I missed the chat! I am on West Coast time instead of my usual East Coast time zone and got all messed up. Looks like it was a great chat, as usual!
GYN Cancer | #GYNCSM @gyncsm
May 8th is also World #OvarianCancer Day! Learn more via @OvarianCancerDY #gyncsm
#GynCSM content from Twitter.